Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 3/20 | 0.42 |
| ▸ | MEN1 | O00255 | 5/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | IDO1 | P14902 | 1/20 | 0.40 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | CCR2 | P41597 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27544474 | 0.86 | TSHR (0.43) | ALDH1A1KDM4EHPGDHSD17B10TP53 | |
| SCHEMBL27853667 | 0.82 | TP53 (0.62) | ALDH1A1KDM4EHSD17B10TP53MEN1 | |
| SCHEMBL12371073 | 0.79 | KDM4E (0.45) | ALDH1A1KDM4EHPGDHSD17B10TP53 | |
| SCHEMBL1598783 | 0.77 | ALDH1A1 (0.56) | ALDH1A1KDM4EHPGDHSD17B10MEN1 | |
| SCHEMBL13640280 | 0.76 | ALDH1A1 (0.54) | ALDH1A1KDM4EHPGDHSD17B10TP53 | |
| SCHEMBL2591249 | 0.76 | KDM4E (0.49) | ALDH1A1KDM4EHPGDHSD17B10PRMT5 | |
| SCHEMBL18509284 | 0.75 | KDM4E (0.45) | ALDH1A1KDM4EHPGDHSD17B10TP53 | |
| SCHEMBL1422093 | 0.75 | ALDH1A1 (0.55) | ALDH1A1KDM4EHPGDHSD17B10TP53 | |
| SCHEMBL20853226 | 0.74 | ALDH1A1 (0.68) | ALDH1A1KDM4EHPGDHSD17B10TP53 | |
| SCHEMBL19506933 | 0.73 | PRMT5 (0.45) | ALDH1A1KDM4EHPGDHSD17B10MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101141956-B | Use of CRTH2 antagonist compounds in therapy,its preparation method and pharmaceutical uses | OXAGEN LTD | 2011-04-20 | — | — | CN | disclosed |
| CN-101932571-A | Compounds having crth2 antagonist activity | OXAGEN LTD | 2010-12-29 | — | — | CN | disclosed |
| CN-101166721-A | With PGD21-acetic acid-indole derivatives with antagonist activity | OXAGEN LTD (GB) | 2008-04-23 | — | — | CN | disclosed |
| CN-101141956-A | Use of CRTH2 antagonist compounds in therapy | OXAGEN LTD (GB) | 2008-03-12 | — | — | CN | disclosed |
| CN-1867547-A | Compounds having crth2 antagonist activity | OXAGEN LTD (GB) | 2006-11-22 | — | — | CN | disclosed |