Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.54 |
| ▸ | MEN1 | O00255 | 1/20 | 0.54 |
| ▸ | GAA | P10253 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.54 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 3/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 3/20 | 0.40 |
| ▸ | DRD2 | P14416 | 2/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.40 |
| ▸ | HTR2A | P28223 | 1/20 | 0.40 |
| ▸ | HTR2C | P28335 | 1/20 | 0.40 |
| ▸ | PLK1 | P53350 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.38 |
| ▸ | HTR3B | O95264 | 1/20 | 0.38 |
| ▸ | HTR3A | P46098 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20853226 | 0.90 | ALDH1A1 (0.68) | ALDH1A1KDM4ESMN1; SMN2MEN1GAA | |
| SCHEMBL19506933 | 0.86 | PRMT5 (0.45) | ALDH1A1KDM4ESMN1; SMN2MEN1GAA | |
| SCHEMBL18509284 | 0.85 | KDM4E (0.45) | ALDH1A1KDM4ESMN1; SMN2MEN1GAA | |
| SCHEMBL20853332 | 0.78 | PTGS2 (0.46) | ALDH1A1KDM4ESMN1; SMN2MEN1GAA | |
| SCHEMBL26433445 | 0.77 | KDM4E (0.51) | ALDH1A1KDM4ESMN1; SMN2MEN1GAA | |
| SCHEMBL21032897 | 0.77 | PRMT5 (0.42) | ALDH1A1KDM4ESMN1; SMN2MEN1GAA | |
| SCHEMBL12580665 | 0.77 | PRMT5 (0.44) | ALDH1A1KDM4ESMN1; SMN2MEN1GAA | |
| SCHEMBL6325712 | 0.77 | TP53 (0.59) | ALDH1A1KDM4ESMN1; SMN2MEN1GAA | |
| SCHEMBL31021975 | 0.77 | TP53 (0.59) | ALDH1A1KDM4ESMN1; SMN2MEN1GAA | |
| SCHEMBL12466547 | 0.76 | ALDH1A1 (0.66) | ALDH1A1KDM4EMEN1KMT2AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9828359-B2 | Process for the preparation of 3-substituted (indol-1-yl)-acetic acid esters | ATOPIX THERAPEUTICS LIMITED (GB) | 2017-11-28 | — | — | US | disclosed |
| US-20170305879-A1 | PROCESS FOR THE PREPARATION OF 3-SUBSTITUTED (INDOL-1-YL)-ACETIC ACID ESTERS | ZACH SYSTEM SPA (IT) | 2017-10-26 | — | — | US | disclosed |
| US-9102658-B2 | Process for the preparation of (5-fluoro-2-methyl-3-quinolin-2-ylmethyl-indol-1-y1)-acetic acid esters | ATOPIX THERAPEUTICS LIMITED (GB) | 2015-08-11 | — | — | US | disclosed |
| US-8980918-B2 | Amorphous (5-fluoro-2-methyl-3-quinolin-2-ylmethyl-indol-1-yl)-acetic acid | ATOPIX THERAPEUTICS LIMITED (GB) | 2015-03-17 | — | — | US | disclosed |
| US-20140350264-A1 | Process for the Preparation of (5-Fluoro-2-methyl-3-quinolin-2-ylmethyl-indol-1-yl)-Acetic Acid Esters | OXAGEN LIMITED (GB) | 2014-11-27 | — | — | US | disclosed |
| US-20140255340-A1 | Amorphous (5-Fluoro-2-methyl-3-quinolin-2-ylmethyl-indol-1-yl)-Acetic Acid | ATOPIX THERAPEUTICS LIMITED (GB) | 2014-09-11 | — | — | US | disclosed |
| US-8703956-B2 | Amorphous (5-fluoro-2-methyl-3-quinolin-2-ylmethyl-indol-1-yl)-acetic acid | ATOPIX THERAPEUTICS LIMITED (GB) | 2014-04-22 | — | — | US | disclosed |
| US-20120282223-A1 | Amorphous (5-Fluoro-2-methyl-3-quinolin-2-ylmethyl-indol-1-yl)-Acetic Acid | ATOPIX THERAPEUTICS LIMITED (GB) | 2012-11-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140255340-A1 | Amorphous (5-Fluoro-2-methyl-3-quinolin-2-ylmethyl-indol-1-yl)-Acetic Acid | HRH2, PTGDR2, PTGDR | ALDH1A1 1129/4885KDM4E 4491/4885SMN1; SMN2 4480/4885 |
| US-20120282223-A1 | Amorphous (5-Fluoro-2-methyl-3-quinolin-2-ylmethyl-indol-1-yl)-Acetic Acid | HRH2, PTGDR2, PTGDR | ALDH1A1 1129/4885KDM4E 4491/4885SMN1; SMN2 4480/4885 |
| US-20140350264-A1 | Process for the Preparation of (5-Fluoro-2-methyl-3-quinolin-2-ylmethyl-indol-1-yl)-Acetic Acid Esters | ADH1C, ALDH7A1, AKR1C1 | ALDH1A1 15/4885KDM4E 595/4885SMN1; SMN2 2466/4885 |
| US-20170305879-A1 | PROCESS FOR THE PREPARATION OF 3-SUBSTITUTED (INDOL-1-YL)-ACETIC ACID ESTERS | IDO1, IDO2, SI | ALDH1A1 55/4885KDM4E 1013/4885SMN1; SMN2 3979/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.