SCHEMBL12372005

SCHEMBL12372005

C(=N/C1CCCCC1)\c1ccc[nH]1

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 4/20 0.47
GRIN2D O15399 1/20 0.43
GRIN3B O60391 1/20 0.43
GRIN1 Q05586 1/20 0.43
GRIN2A Q12879 1/20 0.43
GRIN2B Q13224 1/20 0.43
GRIN2C Q14957 1/20 0.43
GRIN3A Q8TCU5 1/20 0.43
ALDH1A1 P00352 6/20 0.42
MAPT P10636 5/20 0.42
MPI P34949 1/20 0.42
LMNA P02545 3/20 0.41
SMN1; SMN2 Q16637 3/20 0.41
GAA P10253 3/20 0.41
MEN1 O00255 3/20 0.41
HSD17B10 Q99714 2/20 0.41
TSHR P16473 1/20 0.41
HTT P42858 1/20 0.41
PSMD14 O00487 1/20 0.38
MMP2 P08253 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14337283 0.98 KMT2A (0.44) KMT2AGRIN2DGRIN3BGRIN1GRIN2A
SCHEMBL13448857 0.85 L3MBTL1 (0.46) KMT2AGRIN2DGRIN3BGRIN1GRIN2A
SCHEMBL14337459 0.78 GRIN2D (0.38) KMT2AGRIN2DGRIN3BGRIN1GRIN2A
SCHEMBL14337249 0.76 GRIN2D (0.36) KMT2AGRIN2DGRIN3BGRIN1GRIN2A
SCHEMBL14337243 0.71 KMT2A (0.45) KMT2AALDH1A1MAPTMPILMNA
SCHEMBL14337288 0.71 HRH3 (0.46) KMT2AALDH1A1MAPTMPITSHR
SCHEMBL8418576 0.71 KMT2A (0.67) KMT2AALDH1A1MAPTMPILMNA
SCHEMBL8418574 0.71 KMT2A (0.67) KMT2AALDH1A1MAPTMPILMNA
SCHEMBL20915092 0.71 GRIN2D (0.67) KMT2AGRIN2DGRIN3BGRIN1GRIN2A
SCHEMBL20915093 0.71 GRIN2D (0.67) KMT2AGRIN2DGRIN3BGRIN1GRIN2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2350106-B1 PHOSPHORESCENT IRIDIUM COMPLEXES BOE TECHNOLOGY GROUP CO LTD (CN) 2018-05-09 EP disclosed
US-7989580-B2 Phosphorescent iridium complexes GENERAL ELECTRIC COMPANY (US) 2011-08-02 US disclosed
WO-2010051100-A1 PHOSPHORESCENT IRIDIUM COMPLEXES GENERAL ELECTRIC COMPANY (US) 2010-05-06 WO disclosed
US-20100105852-A1 PHOSPHORESCENT IRIDIUM COMPLEXES GENERAL ELECTRIC COMPANY (US) 2010-04-29 US disclosed
US-20100105852-A1 PHOSPHORESCENT IRIDIUM COMPLEXES GENERAL ELECTRIC COMPANY (US) 2010-04-29 US disclosed
EP-1008595-B1 Olefin polymerization catalyst and process for olefin polymerization MITSUI CHEMICALS INC (JP) 2008-09-10 EP disclosed
US-7312284-B2 Process for producing polar olefin copolymer and polar olefin copolymer obtained thereby MITSUI CHEMICALS, INC. (JP) 2007-12-25 US disclosed
US-7312284-B2 Process for producing polar olefin copolymer and polar olefin copolymer obtained thereby MITSUI CHEMICALS, INC. (JP) 2007-12-25 US disclosed
EP-1832609-A2 Process for producing a copolymer of a non-polar olefin and a polar olefin and the copolymer obtained thereby Mitsui Chemicals, Inc. (JP) 2007-09-12 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100105852-A1 PHOSPHORESCENT IRIDIUM COMPLEXES IGF1R, IRS1, IGF2R KMT2A 1451/4885GRIN2D 2741/4885GRIN3B 2329/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.