Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.70 |
| ▸ | RAB9A | P51151 | 3/20 | 0.70 |
| ▸ | MEN1 | O00255 | 2/20 | 0.70 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.70 |
| ▸ | MMP1 | P03956 | 11/20 | 0.57 |
| ▸ | MMP2 | P08253 | 11/20 | 0.57 |
| ▸ | MMP9 | P14780 | 11/20 | 0.57 |
| ▸ | EGFR | P00533 | 9/20 | 0.57 |
| ▸ | MAPT | P10636 | 2/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.56 |
| ▸ | MAOA | P21397 | 4/20 | 0.54 |
| ▸ | MAOB | P27338 | 4/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.54 |
| ▸ | TOP2A | P11388 | 1/20 | 0.53 |
| ▸ | DEGS1 | O15121 | 1/20 | 0.52 |
| ▸ | ALPG | P10696 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12373209 | 0.89 | L3MBTL1 (0.61) | NPC1RAB9AMEN1KMT2AMMP1 | |
| SCHEMBL16221616 | 0.85 | NPC1 (0.81) | NPC1RAB9AMEN1KMT2AMMP1 | |
| SCHEMBL24579667 | 0.79 | KMT2A (0.64) | NPC1RAB9AMEN1KMT2AMAPT | |
| SCHEMBL16221617 | 0.78 | NPC1 (0.64) | NPC1RAB9AMEN1KMT2AMMP1 | |
| SCHEMBL1996366 | 0.78 | MMP1 (0.72) | NPC1RAB9AMEN1KMT2AMMP1 | |
| SCHEMBL1996368 | 0.78 | MMP1 (0.72) | NPC1RAB9AMEN1KMT2AMMP1 | |
| SCHEMBL12555382 | 0.77 | MEN1 (0.72) | NPC1RAB9AMEN1KMT2AMMP1 | |
| SCHEMBL6582272 | 0.76 | NPC1 (0.60) | NPC1RAB9AMEN1KMT2AMMP1 | |
| SCHEMBL6582277 | 0.76 | NPC1 (0.60) | NPC1RAB9AMEN1KMT2AMMP1 | |
| SCHEMBL28609662 | 0.75 | SMN1; SMN2 (0.74) | NPC1RAB9AMEN1KMT2AMMP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110201576-A1 | Small molecule inhibitors of stat3 with anti-tumor activity | H. LEE MOFFITT CANCER CENTER & RESEARCH INSTITUTE (US) | 2011-08-18 | — | — | US | disclosed |
| US-20090069420-A1 | Small molecule inhibitors of STAT3 with anti-tumor activity | H. LEE MOFFITT CANCER CENTER & RESEARCH INSTITUTE (US) | 2009-03-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110201576-A1 | Small molecule inhibitors of stat3 with anti-tumor activity | STAT3, STAT1, STAT5A | NPC1 904/4885RAB9A 2823/4885MEN1 2273/4885 |
| US-20090069420-A1 | Small molecule inhibitors of STAT3 with anti-tumor activity | STAT3, STAT1, STAT5A | NPC1 904/4885RAB9A 2823/4885MEN1 2273/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.