Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.66 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.59 |
| ▸ | HTT | P42858 | 1/20 | 0.57 |
| ▸ | CRBN | Q96SW2 | 2/20 | 0.50 |
| ▸ | THRB | P10828 | 1/20 | 0.48 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.47 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 3/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | HCAR3 | P49019 | 2/20 | 0.45 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.45 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.44 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.44 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.44 |
| ▸ | RXRA | P19793 | 1/20 | 0.43 |
| ▸ | ESR1 | P03372 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12136777 | 0.84 | HSD17B10 (0.52) | SMN1; SMN2HSD17B10HTTCRBNTHRB | |
| SCHEMBL2281814 | 0.83 | SMN1; SMN2 (0.55) | SMN1; SMN2HSD17B10HTTCRBNTHRB | |
| SCHEMBL463732 | 0.78 | SMN1; SMN2 (0.53) | SMN1; SMN2HSD17B10HTTHPGDL3MBTL1 | |
| SCHEMBL13750435 | 0.78 | PDE10A (0.49) | SMN1; SMN2HSD17B10HTTCRBNKDM4E | |
| SCHEMBL12374636 | 0.78 | SMN1; SMN2 (0.57) | SMN1; SMN2HSD17B10HTTTHRBSIRT2 | |
| Hydrochloric Acid SCHEMBL440736 | 0.77 | SMN1; SMN2 (0.52) | SMN1; SMN2HSD17B10HTTHPGDL3MBTL1 | |
| SCHEMBL12374601 | 0.75 | TRPV1 (0.51) | SMN1; SMN2CRBNKDM4EALDH1A1GAA | |
| SCHEMBL29784251 | 0.74 | HSD17B10 (1.00) | SMN1; SMN2HSD17B10HTTTHRBHPGD | |
| SCHEMBL120600 | 0.74 | HSD17B10 (1.00) | SMN1; SMN2HSD17B10HTTTHRBHPGD | |
| SCHEMBL29829098 | 0.74 | SIRT2 (0.58) | SMN1; SMN2HSD17B10HTTTHRBSIRT2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8470819-B2 | Benzimidazole and aza-benzimidazole carboxamides | MERCK SHARP & DOHME CORP. (US) | 2013-06-25 | — | — | US | disclosed |
| US-20110207750-A1 | BENZIMIDAZOLE AND AZA-BENZIMIDAZOLE CARBOXAMIDES | MERCK SHARP & DOHME LLC | 2011-08-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110207750-A1 | BENZIMIDAZOLE AND AZA-BENZIMIDAZOLE CARBOXAMIDES | PAFAH1B3, PAFAH1B2, PAF1 | SMN1; SMN2 3978/4885HSD17B10 3937/4885HTT 4547/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.