Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 12/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.51 |
| ▸ | HPGD | P15428 | 2/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.50 |
| ▸ | BRD2 | P25440 | 2/20 | 0.49 |
| ▸ | BRD3 | Q15059 | 2/20 | 0.49 |
| ▸ | BRDT | Q58F21 | 2/20 | 0.49 |
| ▸ | TRIM24 | O15164 | 1/20 | 0.49 |
| ▸ | BRD1 | O95696 | 1/20 | 0.49 |
| ▸ | CCL2 | P13500 | 1/20 | 0.49 |
| ▸ | TAF1 | P21675 | 1/20 | 0.49 |
| ▸ | SMARCA2 | P51531 | 1/20 | 0.49 |
| ▸ | SMARCA4 | P51532 | 1/20 | 0.49 |
| ▸ | BRPF1 | P55201 | 1/20 | 0.49 |
| ▸ | EP300 | Q09472 | 1/20 | 0.49 |
| ▸ | BPTF | Q12830 | 1/20 | 0.49 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12376655 | 0.88 | BRD4 (0.57) | BRD4ALDH1A1BRD2BRD3BRDT | |
| SCHEMBL14460019 | 0.84 | BRD4 (0.69) | BRD4ALDH1A1HPGDLMNAMAPT | |
| SCHEMBL2285071 | 0.81 | ADRA1D (0.59) | BRD4ALDH1A1HPGDLMNAMAPT | |
| SCHEMBL15241737 | 0.81 | BRD4 (0.54) | BRD4ALDH1A1HPGDLMNAMAPT | |
| SCHEMBL13101588 | 0.81 | BRD4 (0.73) | BRD4ALDH1A1LMNAMAPTHTT | |
| SCHEMBL13101585 | 0.78 | ALDH1A1 (0.51) | BRD4ALDH1A1MAPTHTTBRD2 | |
| SCHEMBL8114228 | 0.74 | ADRA1D (0.61) | ALDH1A1HPGDLMNAMAPTHTT | |
| SCHEMBL13234792 | 0.73 | FLT3 (0.59) | MEN1RAB9AKMT2A | |
| SCHEMBL28377750 | 0.73 | RAB9A (0.57) | BRD4ALDH1A1HPGDLMNAMAPT | |
| SCHEMBL18616245 | 0.73 | BRD4 (0.76) | BRD4ALDH1A1HPGDLMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8003662-B2 | Heterobicyclic thiophene compounds and methods of use | ARRAY BIOPHARMA, INC. (US) | 2011-08-23 | — | — | US | disclosed |
| US-8003662-B2 | Heterobicyclic thiophene compounds and methods of use | ARRAY BIOPHARMA, INC. (US) | 2011-08-23 | — | — | US | disclosed |
| US-20070197537-A1 | Heterobicyclic thiophene compounds and methods of use | ARRAY BIOPHARMA, INC. | 2007-08-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070197537-A1 | Heterobicyclic thiophene compounds and methods of use | ERBB2, LCK, SRC | BRD4 4102/4885ALDH1A1 1635/4885HPGD 1640/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.