Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 5/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.39 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 3/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | ILK | Q13418 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1237271 | 0.85 | MAPT (0.39) | KMT2AMAPTHTTPIK3CAPIK3C3 | |
| Hydrochloric Acid SCHEMBL1236877 | 0.84 | MAPT (0.38) | KMT2AMAPTHTTPIK3CAPIK3C3 | |
| SCHEMBL1236640 | 0.81 | PIK3CG (0.48) | PIK3CAPIK3C3 | |
| SCHEMBL1236713 | 0.80 | KMT2A (0.40) | KMT2AMAPTHTTMEN1NPSR1 | |
| SCHEMBL49123 | 0.77 | L3MBTL1 (0.47) | KMT2AMAPTHTTPIK3CAPIK3C3 | |
| Bromide SCHEMBL48510 | 0.76 | L3MBTL1 (0.46) | KMT2AMAPTHTTPIK3CAPIK3C3 | |
| SCHEMBL13572263 | 0.75 | NPC1 (0.41) | KMT2AMAPTHTTPIK3CAMEN1 | |
| SCHEMBL1237331 | 0.74 | CA12 (0.39) | KMT2AMAPTHTTMEN1NPSR1 | |
| SCHEMBL13572105 | 0.73 | LMNA (0.40) | KMT2AMAPTHTTPIK3CAMEN1 | |
| SCHEMBL998661 | 0.73 | MMP1 (0.43) | KMT2AMAPTHTTMEN1NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 22 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8399497-B2 | Thiazole derivatives and use thereof | MERCK SERONO SA (CH) | 2013-03-19 | — | — | US | claimed |
| EP-1885716-B1 | THIAZOLE DERIVATIVES AND USE THEREOF | MERCK SERONO SA (CH) | 2012-11-07 | — | — | EP | claimed |
| US-20110086843-A1 | Thiazole Derivatives and Use Thereof | MERCK SERONO SA (CH) | 2011-04-14 | — | — | US | claimed |
| US-7879888-B2 | N-(4-methyl-5-{5-[(prop-2-yn-1-ylamino)sulfonyl]-2-thienyl}-1,3-thiazol-2-yl)acetamide; autoimmune disorders and/or inflammatory diseases, cardiovascular diseases, neurodegenerative diseases, bacterial or viral infections, kidney diseases, platelet aggregation, cancer, transplantation, graft rejection | MERCK SERONO SA (CH) | 2011-02-01 | — | — | US | claimed |
| US-20080221180-A1 | Thiazole Derivatives and Use Thereof | LABORATORIES SERONO SA (CH) | 2008-09-11 | — | — | US | claimed |
| EP-1885716-A1 | THIAZOLE DERIVATIVES AND USE THEREOF | Laboratoires Serono SA (CH) | 2008-02-13 | — | — | EP | claimed |
| WO-2006125803-A1 | THIAZOLE DERIVATIVES AND USE THEREOF | LABORATOIRES SERONO S.A. (CH) | 2006-11-30 | — | — | WO | claimed |
| US-8399497-B2 | Thiazole derivatives and use thereof | MERCK SERONO SA (CH) | 2013-03-19 | — | — | US | disclosed |
| US-8399497-B2 | Thiazole derivatives and use thereof | MERCK SERONO SA (CH) | 2013-03-19 | — | — | US | disclosed |
| US-8399497-B2 | Thiazole derivatives and use thereof | MERCK SERONO SA (CH) | 2013-03-19 | — | — | US | disclosed |
| EP-1885716-B1 | THIAZOLE DERIVATIVES AND USE THEREOF | MERCK SERONO SA (CH) | 2012-11-07 | — | — | EP | disclosed |
| EP-1885716-B1 | THIAZOLE DERIVATIVES AND USE THEREOF | MERCK SERONO SA (CH) | 2012-11-07 | — | — | EP | disclosed |
| US-20110086843-A1 | Thiazole Derivatives and Use Thereof | MERCK SERONO SA (CH) | 2011-04-14 | — | — | US | disclosed |
| US-7879888-B2 | N-(4-methyl-5-{5-[(prop-2-yn-1-ylamino)sulfonyl]-2-thienyl}-1,3-thiazol-2-yl)acetamide; autoimmune disorders and/or inflammatory diseases, cardiovascular diseases, neurodegenerative diseases, bacterial or viral infections, kidney diseases, platelet aggregation, cancer, transplantation, graft rejection | MERCK SERONO SA (CH) | 2011-02-01 | — | — | US | disclosed |
| US-7879888-B2 | N-(4-methyl-5-{5-[(prop-2-yn-1-ylamino)sulfonyl]-2-thienyl}-1,3-thiazol-2-yl)acetamide; autoimmune disorders and/or inflammatory diseases, cardiovascular diseases, neurodegenerative diseases, bacterial or viral infections, kidney diseases, platelet aggregation, cancer, transplantation, graft rejection | MERCK SERONO SA (CH) | 2011-02-01 | — | — | US | disclosed |
| US-20080221180-A1 | Thiazole Derivatives and Use Thereof | LABORATORIES SERONO SA (CH) | 2008-09-11 | — | — | US | disclosed |
| US-20080221180-A1 | Thiazole Derivatives and Use Thereof | LABORATORIES SERONO SA (CH) | 2008-09-11 | — | — | US | disclosed |
| US-20080221180-A1 | Thiazole Derivatives and Use Thereof | LABORATORIES SERONO SA (CH) | 2008-09-11 | — | — | US | disclosed |
| EP-1885716-A1 | THIAZOLE DERIVATIVES AND USE THEREOF | Laboratoires Serono SA (CH) | 2008-02-13 | — | — | EP | disclosed |
| WO-2006125803-A1 | THIAZOLE DERIVATIVES AND USE THEREOF | LABORATOIRES SERONO S.A. (CH) | 2006-11-30 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080221180-A1 | Thiazole Derivatives and Use Thereof | PDGFRB, PDGFRA, TEC | KMT2A 4737/4885MAPT 1418/4885HTT 1558/4885 |
| US-20110086843-A1 | Thiazole Derivatives and Use Thereof | PDGFRB, PDGFRA, TEC | KMT2A 4737/4885MAPT 1418/4885HTT 1558/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.