SCHEMBL12376726

SCHEMBL12376726

Cc1ccc(OC(C)C(=O)Nc2ccc(NC(=O)Nc3ccc(C#N)cc3)c(O)c2)c(C)c1

nearest known ligand 0.52

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PABPC1 P11940 1/20 0.52
EIF4H Q15056 1/20 0.52
CXCR2 P25025 3/20 0.48
CXCR1 P25024 2/20 0.48
LMNA P02545 4/20 0.43
SMN1; SMN2 Q16637 3/20 0.43
NPSR1 Q6W5P4 2/20 0.43
KMT2A Q03164 6/20 0.42
MEN1 O00255 5/20 0.42
MAPT P10636 4/20 0.42
MAPK1 P28482 3/20 0.42
IMPDH2 P12268 2/20 0.42
MCL1 Q07820 1/20 0.42
ALDH1A1 P00352 2/20 0.41
L3MBTL1 Q9Y468 1/20 0.41
TRPM4 Q8TD43 1/20 0.41
RAB9A P51151 2/20 0.41
NPC1 O15118 1/20 0.41
KDM4E B2RXH2 2/20 0.41
GAA P10253 2/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14002114 0.87 PABPC1 (0.48) PABPC1EIF4HCXCR2LMNASMN1; SMN2
SCHEMBL14028726 0.84 PABPC1 (0.59) PABPC1EIF4HCXCR2LMNASMN1; SMN2
SCHEMBL14577467 0.83 MAPT (0.49) PABPC1EIF4HCXCR2CXCR1LMNA
SCHEMBL6565641 0.81 CXCR2 (0.68) CXCR2CXCR1LMNASMN1; SMN2KMT2A
SCHEMBL14002111 0.74 PABPC1 (0.57) PABPC1EIF4HLMNASMN1; SMN2NPSR1
SCHEMBL12352217 0.73 PABPC1 (0.55) PABPC1EIF4HLMNASMN1; SMN2NPSR1
SCHEMBL14002120 0.73 PABPC1 (0.40) PABPC1EIF4HLMNASMN1; SMN2NPSR1
SCHEMBL13691695 0.73 MAPT (0.43) CXCR2CXCR1LMNASMN1; SMN2KMT2A
SCHEMBL11085000 0.72 MEN1 (0.56) LMNAKMT2AMEN1MAPTMAPK1
SCHEMBL10957092 0.71 CXCR2 (0.60) CXCR2CXCR1LMNASMN1; SMN2KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7998665-B2 Color intermediate motion picture film EASTMAN KODAK COMPANY (US) 2011-08-16 US disclosed
US-20100167218-A1 COLOR INTERMEDIATE MOTION PICTURE FILM EASTMAN KODAK COMPANY 2010-07-01 US disclosed
US-20090325108-A1 COLOR PHOTOGRAPHIC MATERIALS WITH MAGENTA MINIMUM DENSITY DYES LASER PACIFIC MEDIA CORPORATION 2009-12-31 US disclosed
US-7632632-B1 Color photographic materials with magenta minimum density dyes EASTMAN KODAK COMPANY (US) 2009-12-15 US disclosed
US-7629112-B1 Color photographic materials with yellow minimum density colorants EASTMAN KODAK COMPANY (US) 2009-12-08 US disclosed
US-20090297992-A1 COLOR PHOTOGRAPHIC MATERIALS WITH YELLOW MINIMUM DENSITY COLORANTS KODAK (NEAR EAST) INC. 2009-12-03 US disclosed
US-20090233247-A1 INFRARED DYE FOR SILVER HALIDE-BASED PHOTOGRAPHIC ELEMENTS EASTMAN KODAK COMPANY 2009-09-17 US disclosed
US-20090234131-A1 INFRARED DYE FOR SILVER HALIDE-BASED PHOTOGRAPHIC ELEMENTS EASTMAN KODAK COMPANY (US) 2009-09-17 US disclosed
US-7175975-B2 Photographic material with improved development inhibitor releases EASTMAN KODAK COMPANY (US) 2007-02-13 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090234131-A1 INFRARED DYE FOR SILVER HALIDE-BASED PHOTOGRAPHIC ELEMENTS IK, HTT, HYPK PABPC1 1639/4885EIF4H 1921/4885CXCR2 3929/4885
US-20090233247-A1 INFRARED DYE FOR SILVER HALIDE-BASED PHOTOGRAPHIC ELEMENTS IK, HYPK, HTT PABPC1 1739/4885EIF4H 1677/4885CXCR2 4250/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.