Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CXCR2 | P25025 | 3/20 | 0.68 |
| ▸ | CXCR1 | P25024 | 2/20 | 0.67 |
| ▸ | MAPT | P10636 | 5/20 | 0.54 |
| ▸ | LMNA | P02545 | 3/20 | 0.54 |
| ▸ | TSHR | P16473 | 1/20 | 0.54 |
| ▸ | HTT | P42858 | 1/20 | 0.54 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.54 |
| ▸ | MEN1 | O00255 | 5/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.54 |
| ▸ | RAB9A | P51151 | 3/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.52 |
| ▸ | SAE1 | Q9UBE0 | 1/20 | 0.52 |
| ▸ | UBA2 | Q9UBT2 | 1/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | PKM | P14618 | 1/20 | 0.52 |
| ▸ | IL18 | Q14116 | 1/20 | 0.52 |
| ▸ | CA12 | O43570 | 2/20 | 0.52 |
| ▸ | CA1 | P00915 | 2/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4359536 | 0.86 | CXCR1 (0.70) | CXCR2CXCR1MAPTLMNATSHR | |
| SCHEMBL11054936 | 0.83 | MAPT (0.69) | MAPTLMNATSHRHTTNLRP3 | |
| SCHEMBL8982693 | 0.83 | CXCR2 (0.67) | CXCR2CXCR1MAPTLMNATSHR | |
| SCHEMBL6567616 | 0.81 | CXCR2 (0.73) | CXCR2MAPTLMNAHTTNLRP3 | |
| SCHEMBL12376726 | 0.81 | PABPC1 (0.52) | CXCR2CXCR1MAPTLMNAMEN1 | |
| SCHEMBL5605320 | 0.81 | CXCR2 (1.00) | CXCR2CXCR1MAPTTSHRHTT | |
| SCHEMBL10957092 | 0.81 | CXCR2 (0.60) | CXCR2CXCR1MAPTLMNATSHR | |
| SCHEMBL5594683 | 0.80 | CXCR1 (0.70) | CXCR2CXCR1MAPTLMNATSHR | |
| SCHEMBL7489930 | 0.80 | CXCR2 (1.00) | CXCR2CXCR1MAPTLMNATSHR | |
| SCHEMBL9267208 | 0.79 | CXCR1 (0.70) | CXCR2CXCR1MAPTLMNATSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1402887-A1 | New compounds for the inhibition of undesired cell proliferation and use thereof | Jerini AG (DE) | 2004-03-31 | — | — | EP | claimed |
| EP-1402888-A1 | The use of substituted carbocyclic compounds as rotamases inhibitors | Jerini AG (DE) | 2004-03-31 | — | — | EP | claimed |