Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYR | P14679 | 6/20 | 0.39 |
| ▸ | ERN1 | O75460 | 1/20 | 0.39 |
| ▸ | IDO1 | P14902 | 1/20 | 0.34 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.32 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 3/20 | 0.31 |
| ▸ | MEN1 | O00255 | 2/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4290170 | 0.81 | TYR (0.39) | TYRERN1IDO1ALOX5SLC6A4 | |
| SCHEMBL17928534 | 0.78 | TYR (0.65) | TYRALOX5MAPTMEN1KMT2A | |
| SCHEMBL1539516 | 0.77 | IDO1 (0.38) | IDO1SLC6A4 | |
| SCHEMBL283006 | 0.75 | IDO1 (0.36) | IDO1SLC6A4 | |
| SCHEMBL28646542 | 0.74 | CASP1 (0.46) | TYRMAPTMEN1KMT2ACYP3A4 | |
| SCHEMBL13264635 | 0.74 | TYR (0.38) | TYRALOX5 | |
| SCHEMBL14430064 | 0.74 | TRPA1 (0.52) | TYRMAPTMEN1KMT2ATP53 | |
| SCHEMBL12478909 | 0.74 | ERN1 (0.47) | TYRERN1IDO1 | |
| SCHEMBL18982159 | 0.71 | POLB (0.58) | TYR | |
| SCHEMBL764585 | 0.71 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1904047-B1 | APOPTOSIS PROMOTERS | ABBOTT LAB (US) | 2013-01-02 | — | — | EP | disclosed |
| US-7989656-B2 | Biaryl carboxylic acid apoptosis promoters | ABBOTT LABORATORIES (US) | 2011-08-02 | — | — | US | disclosed |
| US-20100234456-A1 | APOPTOSIS PROMOTERS | ABBOTT LABORATORIES (US) | 2010-09-16 | — | — | US | disclosed |
| US-7750004-B2 | Apoptosis promoters | ABBOTT LABORATORIES (US) | 2010-07-06 | — | — | US | disclosed |
| US-20070135392-A1 | Apoptosis promoters | ABBVIE INC. | 2007-06-14 | — | — | US | disclosed |
| WO-2007008627-A2 | APOPTOSIS PROMOTERS | ABBOTT LABORATORIES (US) | 2007-01-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100234456-A1 | APOPTOSIS PROMOTERS | MCL1, BAX, BCL2 | TYR 4503/4885ERN1 623/4885IDO1 4276/4885 |
| US-20070135392-A1 | Apoptosis promoters | MCL1, BAX, BCL2 | TYR 4503/4885ERN1 623/4885IDO1 4276/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.