SCHEMBL12376951

SCHEMBL12376951

COc1ccc(-c2ccc(OC(=O)c3ccc(C(C)=O)cc3)cc2)cc1

nearest known ligand 0.60

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ LMNA P02545 2/20 0.60
▸ CYP1A2 P05177 1/20 0.60
▸ CYP2C9 P11712 1/20 0.60
▸ CYP2C19 P33261 1/20 0.60
▸ SMN1; SMN2 Q16637 1/20 0.60
▸ KMT2A Q03164 9/20 0.59
▸ MAPT P10636 5/20 0.56
▸ GFER P55789 1/20 0.56
▸ PRSS1 P07477 1/20 0.56
▸ ACR P10323 1/20 0.56
▸ CA1 P00915 1/20 0.56
▸ CA2 P00918 1/20 0.56
▸ RAB9A P51151 2/20 0.50
▸ KDM4E B2RXH2 1/20 0.50
▸ ALDH1A1 P00352 1/20 0.50
▸ HPGD P15428 1/20 0.50
▸ NPC1 O15118 1/20 0.50
▸ CES2 O00748 1/20 0.50
▸ CES1 P23141 1/20 0.50
▸ HSD17B10 Q99714 1/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2742858 1.00 LMNA (0.60) LMNACYP1A2CYP2C9CYP2C19SMN1; SMN2
SCHEMBL15854280 1.00 LMNA (0.60) LMNACYP1A2CYP2C9CYP2C19SMN1; SMN2
SCHEMBL4329847 1.00 LMNA (0.60) LMNACYP1A2CYP2C9CYP2C19SMN1; SMN2
SCHEMBL18675886 0.95 CES2 (0.59) LMNACYP1A2CYP2C9CYP2C19SMN1; SMN2
SCHEMBL12376955 0.95 MAPT (0.59) LMNACYP1A2CYP2C9CYP2C19SMN1; SMN2
SCHEMBL11911278 0.95 LMNA (0.66) LMNACYP1A2CYP2C9CYP2C19SMN1; SMN2
SCHEMBL14817293 0.93 LMNA (0.68) LMNACYP1A2CYP2C9CYP2C19SMN1; SMN2
SCHEMBL16604902 0.93 LMNA (0.68) LMNACYP1A2CYP2C9CYP2C19SMN1; SMN2
SCHEMBL13859676 0.93 LMNA (0.68) LMNACYP1A2CYP2C9CYP2C19SMN1; SMN2
SCHEMBL14430927 0.90 KMT2A (0.50) LMNACYP1A2CYP2C9CYP2C19SMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9746816-B2 Image forming apparatus and electrophotographic cartridge MITSUBISHI CHEMICAL CORPORATION (JP) 2017-08-29 — — US disclosed
US-20170205719-A1 IMAGE FORMING APPARATUS AND ELECTROPHOTOGRAPHIC CARTRIDGE MITSUBISHI CHEMICAL CORPORATION (JP) 2017-07-20 — — US disclosed
US-9703215-B2 Electrophotographic photoreceptor, method of producing same, and electrophotographic apparatus FUJI ELECTRIC CO., LTD. (JP) 2017-07-11 — — US disclosed
US-20160161870-A1 ELECTROPHOTOGRAPHIC PHOTORECEPTOR, METHOD OF PRODUCING SAME, AND ELECTROPHOTOGRAPHIC APPARATUS FUJI ELECTRIC CO., LTD. (JP) 2016-06-09 — — US disclosed
US-9091912-B2 Electrophotographic photosensitive member, process cartridge, and electrophotographic apparatus CANON KABUSHIKI KAISHA (JP) 2015-07-28 — — US disclosed
US-20110206411-A1 IMAGE FORMING APPARATUS AND ELECTROPHOTOGRAPHIC CARTRIDGE MITSUBISHI CHEMICAL CORPORATION (JP) 2011-08-25 — — US disclosed
US-7901855-B2 Electrophotographic photosensitive member, process cartridge and electrophotographic apparatus CANON KABUSHIKI KAISHA (JP) 2011-03-08 — — US disclosed
US-7875410-B2 capable opersistently exerting effect of mitigating contact stress with contact members and improved potential stability during repeated use; polycarbonates CANON KABUSHIKI KAISHA (JP) 2011-01-25 — — US disclosed
US-20100092208-A1 ELECTROPHOTOGRAPHIC PHOTOSENSITIVE MEMBER, PROCESS CARTRIDGE AND ELECTROPHOTOGRAPHIC APPARATUS CANON KABUSHIKI KAISHA (JP) 2010-04-15 — — US disclosed
US-20100092209-A1 ELECTROPHOTOGRAPHIC PHOTOSENSITIVE MEMBER, PROCESS CARTRIDGE AND ELECTROPHOTOGRAPHIC APPARATUS CANON KABUSHIKI KAISHA (JP) 2010-04-15 — — US disclosed
US-7608372-B2 Electrophotographic photoreceptor, electrophotographic image forming method, electrophotographic image forming apparatus, and processing cartridge KONICA MINOLTA BUSINESS TECHNOLOGIES, INC (JP) 2009-10-27 — — US disclosed
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