Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT6 | Q96LA8 | 8/20 | 0.66 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.62 |
| ▸ | HTR7 | P34969 | 1/20 | 0.54 |
| ▸ | BCL2 | P10415 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | NOS1 | P29475 | 3/20 | 0.46 |
| ▸ | PRKACA | P17612 | 1/20 | 0.46 |
| ▸ | PRKACG | P22612 | 1/20 | 0.46 |
| ▸ | PRKACB | P22694 | 1/20 | 0.46 |
| ▸ | AKT2 | P31751 | 1/20 | 0.46 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.45 |
| ▸ | IDO1 | P14902 | 1/20 | 0.45 |
| ▸ | NISCH | Q9Y2I1 | 1/20 | 0.44 |
| ▸ | NOS3 | P29474 | 2/20 | 0.43 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.42 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.41 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8441355 | 0.90 | KDM4E (0.54) | PRMT6EPHX2HTR7KDM4ECYP3A4 | |
| SCHEMBL1252083 | 0.86 | PRMT6 (0.73) | PRMT6EPHX2HTR7KDM4ECYP3A4 | |
| SCHEMBL5547358 | 0.85 | BCL2 (0.62) | PRMT6EPHX2BCL2PTGS2IDO1 | |
| SCHEMBL29489424 | 0.85 | BCL2 (0.62) | PRMT6EPHX2BCL2PTGS2IDO1 | |
| SCHEMBL8986195 | 0.82 | PRMT6 (0.64) | PRMT6EPHX2HTR7KDM4ECYP3A4 | |
| Water SCHEMBL9719807 | 0.81 | BCL2 (0.65) | PRMT6BCL2PTGS2IDO1NISCH | |
| SCHEMBL12305657 | 0.81 | PRMT6 (0.62) | PRMT6EPHX2HTR7KDM4ECYP3A4 | |
| SCHEMBL1697126 | 0.80 | MAPT (0.64) | PRMT6EPHX2HTR7KDM4ECYP3A4 | |
| SCHEMBL14676172 | 0.79 | PRMT6 (1.00) | PRMT6EPHX2HTR7CYP3A4NOS1 | |
| SCHEMBL6414198 | 0.79 | PRMT6 (0.65) | PRMT6EPHX2HTR7KDM4ECYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8008440-B2 | Combinatorial synthesis of libraries of macrocyclic compounds useful in drug discovery | TRANZYME PHARMA INC. (CA) | 2011-08-30 | — | — | US | disclosed |
| US-20070117154-A1 | Cyclic lactams comprising three amino acids and a tether chain to control the overall shape of the macromolecule; beta-turn mimetics to explore conformationally restricted structures; proteolytic enzyme resistance (nonhydrolyzing); cell penetration; anticoagulants; anticarcinogenic agents | MALLINCKRODT PHARMACEUTICALS IRELAND LIMITED (IE) | 2007-05-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070117154-A1 | Cyclic lactams comprising three amino acids and a tether chain to control the overall shape of the macromolecule; beta-turn mimetics to explore conformationally restricted structures; proteolytic enzyme resistance (nonhydrolyzing); cell penetration; anticoagulants; anticarcinogenic agents | F2, BCAT1, DAO | PRMT6 401/4885EPHX2 1524/4885HTR7 4339/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.