SCHEMBL12377293

SCHEMBL12377293

CC(C)n1c(NC(=O)C(N)c2ccc(-c3ccccc3)cc2)nc2cc(C(F)(F)F)cc(Cl)c21

nearest known ligand 0.38

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
PRCP P42785 6/20 0.38
PDE2A O00408 3/20 0.37
TTK P33981 1/20 0.37
NTRK1 P04629 3/20 0.36
ACLY P53396 1/20 0.36
MALT1 Q9UDY8 2/20 0.35
CASR P41180 1/20 0.35
SLC1A3 P43003 1/20 0.35
SLC1A2 P43004 1/20 0.35
SLC1A1 P43005 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12377310 0.87 SLC1A3 (0.41) PRCPACLYCASRSLC1A3SLC1A2
SCHEMBL12377303 0.87 PRCP (0.47) PRCPMALT1SLC1A3SLC1A2SLC1A1
SCHEMBL12377301 0.84 PPARG (0.39) PDE2ATTKSLC1A3SLC1A2SLC1A1
SCHEMBL12377297 0.80 HSD17B10 (0.43)
SCHEMBL12377283 0.77 MAPT (0.42)
SCHEMBL12413913 0.77 SLC1A3 (0.39) ACLYCASRSLC1A3SLC1A2SLC1A1
SCHEMBL12377308 0.75 SPHK1 (0.36)
SCHEMBL12377291 0.72 MET (0.43)
SCHEMBL12377309 0.71 PRCP (0.43) PRCPSLC1A3SLC1A2SLC1A1
SCHEMBL12377294 0.71 SLC1A3 (0.45) SLC1A3SLC1A2SLC1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7989422-B2 Antibacterial agents ALCHEMIA LIMITED (AU) 2011-08-02 US disclosed
US-7989422-B2 Antibacterial agents ALCHEMIA LIMITED (AU) 2011-08-02 US disclosed
US-20090023669-A1 Antibacterial Agents ALCHEMIA LIMITED (AU) 2009-01-22 US disclosed
US-20090023669-A1 Antibacterial Agents ALCHEMIA LIMITED (AU) 2009-01-22 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090023669-A1 Antibacterial Agents MRPL21, FUT6, FUT5 PRCP 1394/4885PDE2A 2984/4885TTK 4479/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.