Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.56 |
| ▸ | THRB | P10828 | 2/20 | 0.55 |
| ▸ | GAA | P10253 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.54 |
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | GSK3B | P49841 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12377814 | 0.85 | GAA (0.54) | MAPTTHRBGAAKMT2ATSHR | |
| SCHEMBL30129915 | 0.84 | MAPT (0.61) | MAPTGAAKMT2APOLB | |
| SCHEMBL12377818 | 0.80 | RAB9A (0.56) | MAPTTHRBGAAKMT2ATSHR | |
| SCHEMBL28816445 | 0.77 | SMPD1 (0.57) | MAPTTHRBGAAKMT2ATSHR | |
| SCHEMBL12377816 | 0.77 | TP53 (0.51) | MAPTTHRBGAAKMT2ATSHR | |
| SCHEMBL15107383 | 0.76 | HAVCR2 (0.53) | MAPTTHRBKMT2ATSHRMEN1 | |
| SCHEMBL44764 | 0.76 | GAA (0.44) | MAPTTHRBGAAKMT2ALMNA | |
| SCHEMBL15107381 | 0.76 | POLB (0.59) | MAPTTHRBGAAKMT2ATSHR | |
| SCHEMBL15107380 | 0.75 | ALDH1A1 (0.53) | MAPTTHRBKMT2ATSHRMEN1 | |
| SCHEMBL13447650 | 0.74 | KMT2A (0.48) | MAPTTHRBKMT2ATSHRLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7998954-B2 | Pyrimidodiazepinone derivative | KYOWA HAKKO KIRIN CO., LTD. (JP) | 2011-08-16 | — | — | US | disclosed |
| US-20100190775-A1 | PYRIMIDODIAZEPINONE DERIVATIVE | KYOWA HAKKO KIRIN CO., LTD (JP) | 2010-07-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100190775-A1 | PYRIMIDODIAZEPINONE DERIVATIVE | KCNJ1, KCNJ11, ADRA1D | MAPT 4573/4885THRB 2232/4885GAA 1762/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.