Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TACR1 | P25103 | 3/20 | 0.33 |
| ▸ | KDM5A | P29375 | 1/20 | 0.30 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.30 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.30 |
| ▸ | LIPG | Q9Y5X9 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12378380 | 0.92 | TACR1 (0.33) | TACR1HSP90AA1LIPG | |
| SCHEMBL12378713 | 0.90 | TACR1 (0.32) | TACR1 | |
| SCHEMBL12378692 | 0.90 | BCL2L1 (0.31) | BCL2L1LIPG | |
| SCHEMBL12378710 | 0.88 | MKNK1 (0.32) | TACR1LIPG | |
| SCHEMBL12378712 | 0.88 | LIPG (0.34) | KDM5ABCL2L1LIPG | |
| SCHEMBL12378698 | 0.87 | KIT (0.30) | — | |
| SCHEMBL12378711 | 0.86 | TACR1 (0.38) | TACR1 | |
| SCHEMBL12378714 | 0.85 | LIPG (0.35) | LIPG | |
| SCHEMBL12378731 | 0.85 | MET (0.34) | — | |
| SCHEMBL12378717 | 0.85 | PREP (0.33) | HSP90AA1LIPG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8008287-B2 | Use treating HIV and AIDS; tricyclic compounds such as those based on 5-sulfonamido-9-hydroxy-6,8-dihydrdo-7H-pyrrolo[3,4-g]quinoline-8-one | GILEAD SCIENCES, INC. (US) | 2011-08-30 | — | — | US | disclosed |