Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR2 | P34972 | 5/20 | 0.38 |
| ▸ | CNR1 | P21554 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 2/20 | 0.32 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | SYK | P43405 | 2/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | LIPG | Q9Y5X9 | 1/20 | 0.31 |
| ▸ | ANO1 | Q5XXA6 | 1/20 | 0.31 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12378423 | 0.93 | CNR2 (0.46) | CNR2CNR1KMT2ASYKLIPG | |
| SCHEMBL12378712 | 0.89 | LIPG (0.34) | KMT2ANPC1MAPTSMN1; SMN2ALDH1A1 | |
| SCHEMBL12378709 | 0.85 | PREP (0.34) | KMT2ANPC1MAPTSMN1; SMN2ALDH1A1 | |
| SCHEMBL12378692 | 0.85 | BCL2L1 (0.31) | NPC1MAPTSMN1; SMN2ALDH1A1LMNA | |
| SCHEMBL13623963 | 0.83 | EGLN1 (0.37) | CNR2KMT2AL3MBTL1LIPGANO1 | |
| SCHEMBL12378702 | 0.83 | TACR1 (0.33) | LIPG | |
| SCHEMBL12378698 | 0.82 | KIT (0.30) | — | |
| SCHEMBL12378700 | 0.81 | KIT (0.30) | — | |
| SCHEMBL4377607 | 0.81 | CNR2 (0.38) | CNR2CNR1KMT2ALMNALIPG | |
| SCHEMBL12378717 | 0.81 | PREP (0.33) | KMT2ANPC1MAPTSMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8008287-B2 | Use treating HIV and AIDS; tricyclic compounds such as those based on 5-sulfonamido-9-hydroxy-6,8-dihydrdo-7H-pyrrolo[3,4-g]quinoline-8-one | GILEAD SCIENCES, INC. (US) | 2011-08-30 | — | — | US | disclosed |