SCHEMBL12378786

SCHEMBL12378786

CC(=O)NCC#Cc1cn([C@H]2CC(O)[C@@H](COP(=O)(O)OP(=O)(O)OP(=O)(O)O)O2)c(=O)[nH]c1=O

nearest known ligand 0.67

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
▸ POLB P06746 2/20 0.54
▸ POLA1 P09884 1/20 0.53
▸ POLD1 P28340 1/20 0.53

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14606222 0.93 POLB (0.53) POLBPOLA1POLD1
SCHEMBL2301090 0.91 POLB (0.52) POLBPOLA1POLD1
SCHEMBL20417783 0.91 POLB (0.51) POLBPOLA1POLD1
SCHEMBL16716006 0.90 POLB (0.57) POLBPOLA1POLD1
SCHEMBL2293561 0.90 POLB (0.51) POLBPOLA1POLD1
SCHEMBL18844329 0.90 POLB (0.51) POLBPOLA1POLD1
SCHEMBL8049881 0.90 POLB (0.51) POLBPOLA1POLD1
SCHEMBL2296337 0.89 POLB (0.49) POLBPOLA1POLD1
SCHEMBL15115325 0.89 POLB (0.49) POLBPOLA1POLD1
SCHEMBL8600185 0.89 POLB (0.56) POLBPOLA1POLD1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8304259-B2 Labeling dye for detecting biomolecule, labeling kit, and method for detecting biomolecule Isobe, Shinichiro (JP) 2012-11-06 — — US disclosed
US-20110195408-A1 Labeling Dye for Detecting Biomolecule, Labeling Kit, and Method for Detecting Biomolecule ISOBE, SHINICHIRO (JP) 2011-08-11 — — US disclosed
US-7662555-B2 Method for detecting biomolecule, labeling dye used therefore, and labeling kit ISOBE SHINICHIRO 2010-02-16 — — US disclosed
US-20070154890-A1 Method for detecting biomolecule, labeling dye used therefore, and labeling kit ISOBE SHINICHIRO 2007-07-05 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110195408-A1 Labeling Dye for Detecting Biomolecule, Labeling Kit, and Method for Detecting Biomolecule EPCAM, MB, MKI67 POLB 1283/4885POLA1 2540/4885POLD1 2642/4885
US-20070154890-A1 Method for detecting biomolecule, labeling dye used therefore, and labeling kit EPCAM, MB, NEFM POLB 937/4885POLA1 3025/4885POLD1 3341/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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