Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B1 | P14061 | 7/20 | 0.69 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | RECQL | P46063 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | STS | P08842 | 7/20 | 0.45 |
| ▸ | ESR1 | P03372 | 2/20 | 0.45 |
| ▸ | CA1 | P00915 | 1/20 | 0.45 |
| ▸ | CA2 | P00918 | 1/20 | 0.45 |
| ▸ | CA4 | P22748 | 1/20 | 0.45 |
| ▸ | CA6 | P23280 | 1/20 | 0.45 |
| ▸ | CA9 | Q16790 | 1/20 | 0.45 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | ABCC1 | P33527 | 1/20 | 0.43 |
| ▸ | SLCO1B1 | Q9Y6L6 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12379642 | 0.82 | HSD17B1 (1.00) | HSD17B1MAPTLMNASTSESR1 | |
| SCHEMBL2289901 | 0.82 | HSD17B1 (1.00) | HSD17B1MAPTLMNASTSESR1 | |
| SCHEMBL1977506 | 0.82 | HSD17B1 (1.00) | HSD17B1MAPTLMNASTSESR1 | |
| SCHEMBL12379708 | 0.82 | HSD17B1 (0.66) | HSD17B1MAPTLMNARECQLSMN1; SMN2 | |
| SCHEMBL10116722 | 0.80 | LMNA (0.70) | HSD17B1MAPTLMNARECQLSMN1; SMN2 | |
| SCHEMBL13168702 | 0.80 | ESR1 (0.62) | HSD17B1MAPTLMNARECQLSMN1; SMN2 | |
| SCHEMBL11315779 | 0.76 | HSD17B1 (0.67) | HSD17B1MAPTLMNARECQLSMN1; SMN2 | |
| SCHEMBL11239229 | 0.76 | HSD17B1 (0.67) | HSD17B1MAPTLMNARECQLSMN1; SMN2 | |
| SCHEMBL12589516 | 0.76 | STS (0.73) | HSD17B1MAPTLMNARECQLSMN1; SMN2 | |
| SCHEMBL14375467 | 0.76 | STS (0.71) | HSD17B1MAPTLMNARECQLSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8003783-B2 | Steroid 17 beta -hydroxysteroid dehydrogenase inhibitors substituted with one or more oxime groups, especially aromatase inhibitors used in the treatment of endocrine-dependent tumors, especially breast cancer | STERIX LIMITED (GB) | 2011-08-23 | — | — | US | disclosed |