SCHEMBL1237991

SCHEMBL1237991

Oc1c[nH]c2ccc(Br)cc12

nearest known ligand 0.58

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
GPR84 Q9NQS5 1/20 0.58
HTR2A P28223 1/20 0.51
TRPM8 Q7Z2W7 1/20 0.51
NR4A2 P43354 1/20 0.51
CSNK2A1 P68400 1/20 0.50
GUSB P08236 3/20 0.49
AR P10275 1/20 0.47
MTNR1A P48039 1/20 0.45
MTNR1B P49286 1/20 0.45
SMN1; SMN2 Q16637 1/20 0.45
L3MBTL1 Q9Y468 1/20 0.45
SLC6A4 P31645 2/20 0.45
IDO1 P14902 1/20 0.44
GABRA1 P14867 1/20 0.44
GABRB1 P18505 1/20 0.44
GABRA3 P34903 1/20 0.44
GABRB2 P47870 1/20 0.44
MEN1 O00255 1/20 0.44
GAA P10253 1/20 0.44
MAPT P10636 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Phosphoric Acid SCHEMBL1232434 0.91 GPR84 (0.50) GPR84HTR2ATRPM8NR4A2CSNK2A1
SCHEMBL28520808 0.91 GPR84 (0.50) GPR84HTR2ATRPM8NR4A2CSNK2A1
Acetic Acid SCHEMBL2543914 0.89 NR4A2 (0.55) GPR84HTR2ATRPM8NR4A2CSNK2A1
Acetic Acid SCHEMBL23525629 0.89 NR4A2 (0.55) GPR84HTR2ATRPM8NR4A2CSNK2A1
SCHEMBL2804219 0.83 CYP2A6 (0.55) GPR84GUSBSLC6A4IDO1
SCHEMBL28207416 0.78 GPR84 (0.62) GPR84HTR2ATRPM8NR4A2CSNK2A1
SCHEMBL5429556 0.78 GPR84 (0.62) GPR84HTR2ATRPM8NR4A2CSNK2A1
SCHEMBL30686491 0.78 HTR2C (0.56) HTR2ASLC6A4MEN1MAPTKMT2A
SCHEMBL5259883 0.78 HTR2C (0.56) HTR2ASLC6A4MEN1MAPTKMT2A
B-D-Galactose SCHEMBL27919531 0.78 ATM (0.44) GPR84HTR2ATRPM8NR4A2CSNK2A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 507 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20240084002-A1 METHODS AND COMPOSITIONS UTILIZING IDO1-DEPENDENT VASCULARIZING CELLS FOR THE TREATMENT OF PATHOLOGICAL CONDITIONS INVOLVING NEOVASCULARIZATION LANKENAU INSTITUTE FOR MEDICAL RESEARCH (US) 2024-03-14 US claimed
EP-4255423-A1 METHODS AND COMPOSITIONS UTILIZING IDO1-DEPENDENT VASCULARIZING CELLS FOR THE TREATMENT OF PATHOLOGICAL CONDITIONS INVOLVING NEOVASCULARIZATION Lankenau Institute for Medical Research (US) 2023-10-11 EP claimed
CN-116806149-A Methods and compositions for treating pathological conditions involving neovascularization using IDO 1-dependent angiogenic cells 兰肯瑙医学研究所 2023-09-26 CN claimed
US-11752131-B2 Methods and pharmaceutical compositions for the treatment of obesity INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE) (FR) 2023-09-12 US claimed
WO-2023161230-A1 THERMOSTABLE GLYCOSYLTRANSFERASE VARIANTS DANMARKS TEKNISKE UNIVERSITET (DK) 2023-08-31 WO claimed
WO-2022125553-A1 METHODS AND COMPOSITIONS UTILIZING IDO1-DEPENDENT VASCULARIZING CELLS FOR THE TREATMENT OF PATHOLOGICAL CONDITIONS INVOLVING NEOVASCULARIZATION LANKENAU INSTITUTE FOR MEDICAL RESEARCH (US) 2022-06-16 WO claimed
EP-2718458-B1 NOVEL METHOD FOR DETECTION OF BETA-D-GLUCURONIDASE BIOSYNTH AG (CH) 2015-07-08 EP claimed
EP-2084293-B1 GENETICALLY ENGINEERED BIOLOGICAL INDICATOR AMERICAN STERILIZER CO (US) 2014-08-13 EP claimed
US-20140212905-A1 Novel Method for Detection of Beta-D-Glucuronidase BIOSYNTH AG (CH) 2014-07-31 US claimed
EP-2718458-A1 NOVEL METHOD FOR DETECTION OF BETA-D-GLUCURONIDASE Biosynth AG (CH) 2014-04-16 EP claimed
US-20020182600-A1 Method for assaying biological and other constituents using synthetic nucleounits in lateral flow, liquid, and dry chemistry techniques SMITH JACK V (US) 2002-12-05 US claimed
US-6420552-B1 GENERATING CHROMOGENIC GLYCOSIDES; OBTAIN NEURAMIC ACID DERIVATIVE, ALKYLATE, DEPROTECT HYDROXYL GROUPS, ACTIVATE ANOMERIC CARBON, INCUBATE WITH CHROMOGEN, REGENERATE HYDROXYL GROUPS, RECOVER CHROMOGENIC GLYCOSIDE ZYMETX, INC. 2002-07-16 US claimed
WO-2002053705-A1 CULTURE MEDIUM FOR DETECTING BACTERIA OF LISTERIA GENUS RAMBACH ALAIN (FR) 2002-07-11 WO claimed
WO-2002000922-A1 VIBRIO BACTERIA DETECTION AND/OR DIFFERENTIATION RAMBACH ALAIN (FR) 2002-01-03 WO claimed
US-6303764-B1 EFFICIENT PREPARATION OF KETOSIDE WHICH IS SUBSTRATE FOR NEURAMINIDASES; FOR USE IN DETECTION OF INFLUENZA VIRUS TYPES A AND B ZYMETX, INC. 2001-10-16 US claimed
US-6165743-A Culture medium for revealing enterohemorrhagic E. coli bacteria and procedure therefor RAMBACH ALAIN (FR) 2000-12-26 US claimed
US-5962251-A INTRODUCING AT LEAST TWO CHROMOGENS WHICH ARE ENZYME SUBSTRATES FOR A MICROORGANISM STRAIN INTO CULTURE MEDIUM, IDENTIFYING ACCESSORY COLOR PRODUCED BY ENZYMATIC ACTIVITY RAMBACH ALAIN (FR) 1999-10-05 US claimed
EP-0711360-B1 Process for the identification of microorganisms using at least two chromogens RAMBACH ALAIN (FR) 1998-03-11 EP claimed
US-5716799-A QUALITATIVE COLORIMETRIC ANALYSIS RAMBACH ALAIN (FR) 1998-02-10 US claimed
EP-0711359-B1 MICROORGANISM IDENTIFICATION METHOD USING A MEDIUM CONTAINING ADDED CARBOHYDRATE RAMBACH ALAIN (FR) 1997-05-28 EP claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240084002-A1 METHODS AND COMPOSITIONS UTILIZING IDO1-DEPENDENT VASCULARIZING CELLS FOR THE TREATMENT OF PATHOLOGICAL CONDITIONS INVOLVING NEOVASCULARIZATION IDO1, IDO2, TIE1 GPR84 1810/4885HTR2A 3120/4885TRPM8 3436/4885
US-11752131-B2 Methods and pharmaceutical compositions for the treatment of obesity IDO1, IDO2, GPR119 GPR84 1077/4885HTR2A 210/4885TRPM8 2787/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.