Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.66 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.57 |
| ▸ | POLB | P06746 | 2/20 | 0.57 |
| ▸ | TACR3 | P29371 | 1/20 | 0.57 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.55 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.55 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.55 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.55 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.55 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.55 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.55 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.55 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.55 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.55 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.55 |
| ▸ | TSHR | P16473 | 1/20 | 0.55 |
| ▸ | USP2 | O75604 | 1/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12424421 | 0.91 | ALDH1A1 (0.62) | L3MBTL1HSD11B1ALDH1A1KDM4EPOLB | |
| SCHEMBL13152714 | 0.84 | L3MBTL1 (0.64) | L3MBTL1HSD11B1ALDH1A1KDM4EPOLB | |
| SCHEMBL15014500 | 0.83 | L3MBTL1 (0.71) | L3MBTL1HSD11B1ALDH1A1KDM4EPOLB | |
| SCHEMBL27547326 | 0.81 | L3MBTL1 (0.79) | L3MBTL1HSD11B1ALDH1A1KDM4EPOLB | |
| SCHEMBL13181132 | 0.81 | HDAC3 (0.68) | L3MBTL1HSD11B1ALDH1A1KDM4EPOLB | |
| SCHEMBL24663632 | 0.81 | L3MBTL1 (0.73) | L3MBTL1HSD11B1ALDH1A1KDM4EPOLB | |
| SCHEMBL12424606 | 0.80 | L3MBTL1 (0.68) | L3MBTL1HSD11B1ALDH1A1KDM4EPOLB | |
| SCHEMBL13629928 | 0.80 | L3MBTL1 (0.77) | L3MBTL1HSD11B1ALDH1A1KDM4EPOLB | |
| SCHEMBL10722408 | 0.80 | HSD11B1 (0.77) | L3MBTL1HSD11B1ALDH1A1KDM4ETSHR | |
| SCHEMBL3967794 | 0.80 | HSD11B1 (0.77) | L3MBTL1HSD11B1ALDH1A1KDM4ETSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8461328-B2 | Tricyclic heterocyclic compounds, compositions and methods of use thereof | GENENTECH, INC. (US) | 2013-06-11 | — | — | US | disclosed |
| US-20110201593-A1 | TRICYCLIC HETEROCYCLIC COMPOUNDS, COMPOSITIONS AND METHODS OF USE THEREOF | GENENTECH, INC. (US) | 2011-08-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110201593-A1 | TRICYCLIC HETEROCYCLIC COMPOUNDS, COMPOSITIONS AND METHODS OF USE THEREOF | CCNY, CCNA1, CCNA2 | L3MBTL1 3165/4885HSD11B1 291/4885ALDH1A1 1168/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.