SCHEMBL12387589

SCHEMBL12387589

Cc1nc(Nc2cccc(O)c2)nc(Nc2ccc(O)c3ccccc23)n1

nearest known ligand 0.49

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ SYK P43405 6/20 0.48
▸ CDC25B P30305 1/20 0.48
▸ MEN1 O00255 4/20 0.46
▸ KMT2A Q03164 4/20 0.46
▸ POLB P06746 1/20 0.46
▸ RAD52 P43351 1/20 0.46
▸ GFER P55789 1/20 0.46
▸ GAA P10253 1/20 0.44
▸ MAPT P10636 1/20 0.44
▸ TAAR1 Q96RJ0 1/20 0.44
▸ NTSR1 P30989 1/20 0.42
▸ CYP3A4 P08684 1/20 0.42
▸ TSHR P16473 1/20 0.42
▸ AURKA O14965 1/20 0.42
▸ EGFR P00533 1/20 0.42
▸ ERBB2 P04626 1/20 0.42
▸ SRC P12931 1/20 0.42
▸ ACVR1 Q04771 1/20 0.42
▸ PTK6 Q13882 1/20 0.42
▸ ALK Q9UM73 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL18391971 0.88 CDC25B (0.48) SYKCDC25BMEN1KMT2APOLB
SCHEMBL13223236 0.88 CDC25B (0.48) SYKCDC25BMEN1KMT2APOLB
SCHEMBL1318687 0.84 SYK (0.63) SYKMEN1KMT2APOLBRAD52
SCHEMBL17130325 0.82 IDO1 (0.53) SYKCDC25BMEN1KMT2APOLB
SCHEMBL12387588 0.81 SYK (0.57) SYKKMT2ACYP3A4TSHRAURKA
SCHEMBL18391969 0.78 KCNH3 (0.58) MEN1KMT2ATAAR1
SCHEMBL25830630 0.77 KCNH3 (0.46) TAAR1
SCHEMBL18385065 0.77 KCNH3 (0.46) TAAR1
SCHEMBL17130323 0.76 CDC25B (0.45) SYKCDC25BMEN1KMT2APOLB
SCHEMBL7564159 0.76 SYK (0.64) SYKMEN1KMT2APOLBRAD52

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9447171-B2 Purification process for fragment antibodies FUJIFILM DIOSYNTH BIOTECHNOLOGIES UK LIMITED (GB) 2016-09-20 — — US disclosed
US-20110190478-A1 Purification Process for Fragment Antibodies FUJIFILM DIOSYNTH BIOTECHNOLOGIES UK LIMITED (GB) 2011-08-04 — — US disclosed
US-20110046353-A1 Purification Process for Anitbody Fragments Using Derivatized Triazines as Affinity Ligands FUJIFILM DIOSYNTH BIOTECHNOLOGIES UK LIMITED (GB) 2011-02-24 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110190478-A1 Purification Process for Fragment Antibodies NEFM, IGLV6-57, FIBP SYK 58/4885CDC25B 3332/4885MEN1 2438/4885
US-20110046353-A1 Purification Process for Anitbody Fragments Using Derivatized Triazines as Affinity Ligands FCGR3B, FCGR2A, NMBR SYK 607/4885CDC25B 2184/4885MEN1 2412/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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