Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.34 |
| ▸ | GAA | P10253 | 4/20 | 0.34 |
| ▸ | HPGD | P15428 | 3/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | USP2 | O75604 | 1/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | TUBB4A | P04350 | 6/20 | 0.33 |
| ▸ | TUBB | P07437 | 6/20 | 0.33 |
| ▸ | TUBA3C | P0DPH7 | 6/20 | 0.33 |
| ▸ | TUBA1B | P68363 | 6/20 | 0.33 |
| ▸ | TUBA4A | P68366 | 6/20 | 0.33 |
| ▸ | TUBB4B | P68371 | 6/20 | 0.33 |
| ▸ | TUBB3 | Q13509 | 6/20 | 0.33 |
| ▸ | TUBB2A | Q13885 | 6/20 | 0.33 |
| ▸ | TUBB8 | Q3ZCM7 | 6/20 | 0.33 |
| ▸ | TUBA3E | Q6PEY2 | 6/20 | 0.33 |
| ▸ | TUBA1A | Q71U36 | 6/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1244015 | 0.81 | KDM4E (0.38) | KDM4EALDH1A1HSD17B10GAAHPGD | |
| SCHEMBL13209985 | 0.77 | TUBB4A (0.45) | KDM4EALDH1A1HSD17B10GAANPSR1 | |
| SCHEMBL12388671 | 0.75 | CCNC (0.35) | KDM4EALDH1A1HSD17B10GAAHPGD | |
| SCHEMBL13395533 | 0.75 | KDM4E (0.34) | KDM4EALDH1A1HSD17B10GAAHPGD | |
| SCHEMBL13395504 | 0.74 | BTK (0.37) | KDM4EALDH1A1HSD17B10 | |
| SCHEMBL13209999 | 0.74 | TP53 (0.44) | KDM4EALDH1A1HPGDMAPTALOX15 | |
| SCHEMBL12388666 | 0.71 | XDH (0.44) | KDM4EALDH1A1HSD17B10GAAHPGD | |
| SCHEMBL13210004 | 0.71 | KDM4E (0.38) | KDM4EALDH1A1HSD17B10GAAHPGD | |
| SCHEMBL8225320 | 0.71 | KDM4E (0.38) | KDM4EALDH1A1HSD17B10GAAHPGD | |
| SCHEMBL12388683 | 0.70 | PARP1 (0.37) | KDM4EALDH1A1HSD17B10GAAHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8901139-B2 | Tricyclic indole derivatives and methods of use thereof | MERCK SHARP & DOHME CORP. (US) | 2014-12-02 | — | — | US | disclosed |
| US-8901139-B2 | Tricyclic indole derivatives and methods of use thereof | MERCK SHARP & DOHME CORP. (US) | 2014-12-02 | — | — | US | disclosed |
| US-8557848-B2 | 4,5-ring annulated indole derivatives for treating or preventing of HCV and related viral infections | MERCK SHARP & DOHME CORP. (US) | 2013-10-15 | — | — | US | disclosed |
| US-8557848-B2 | 4,5-ring annulated indole derivatives for treating or preventing of HCV and related viral infections | MERCK SHARP & DOHME CORP. (US) | 2013-10-15 | — | — | US | disclosed |
| US-20110189127-A1 | TRICYCLIC INDOLE DERIVATIVES AND METHODS OF USE THEREOF | MERCK SHARP & DOHME LLC | 2011-08-04 | — | — | US | disclosed |
| US-20110189127-A1 | TRICYCLIC INDOLE DERIVATIVES AND METHODS OF USE THEREOF | MERCK SHARP & DOHME LLC | 2011-08-04 | — | — | US | disclosed |
| US-20100098661-A1 | 4,5-RING ANNULATED INDOLE DERIVATIVES FOR TREATING OR PREVENTING OF HCV AND RELATED VIRAL INFECTIONS | SCHERING CORPORATION | 2010-04-22 | — | — | US | disclosed |
| US-20100098661-A1 | 4,5-RING ANNULATED INDOLE DERIVATIVES FOR TREATING OR PREVENTING OF HCV AND RELATED VIRAL INFECTIONS | SCHERING CORPORATION | 2010-04-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100098661-A1 | 4,5-RING ANNULATED INDOLE DERIVATIVES FOR TREATING OR PREVENTING OF HCV AND RELATED VIRAL INFECTIONS | ZC3HAV1, IDO1, ZC3HAV1L | KDM4E 405/4885ALDH1A1 248/4885HSD17B10 853/4885 |
| US-20110189127-A1 | TRICYCLIC INDOLE DERIVATIVES AND METHODS OF USE THEREOF | IDO1, IDO2, TPH1 | KDM4E 1597/4885ALDH1A1 1741/4885HSD17B10 514/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.