Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B3 | P37058 | 2/20 | 0.37 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 4/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | BRD4 | O60885 | 1/20 | 0.35 |
| ▸ | BRD2 | P25440 | 1/20 | 0.35 |
| ▸ | BRD3 | Q15059 | 1/20 | 0.35 |
| ▸ | PPARG | P37231 | 1/20 | 0.35 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.35 |
| ▸ | FLT1 | P17948 | 1/20 | 0.34 |
| ▸ | FLT4 | P35916 | 1/20 | 0.34 |
| ▸ | KDR | P35968 | 1/20 | 0.34 |
| ▸ | NAMPT | P43490 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | SRD5A1 | P18405 | 1/20 | 0.34 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13384619 | 0.88 | TDP1 (0.38) | MAPK14NPSR1KDM4ENAMPTHPGD | |
| SCHEMBL12389857 | 0.87 | MAPK14 (0.46) | MEN1KMT2AMAPK14KDM4ENAMPT | |
| SCHEMBL12389206 | 0.87 | SRD5A2 (0.48) | ALDH1A1SRD5A1SRD5A2F11 | |
| SCHEMBL12388910 | 0.86 | PDK2 (0.40) | HSD17B3MAPK14KDM4EBRD4NAMPT | |
| SCHEMBL12365327 | 0.85 | SLC6A3 (0.46) | HSD17B3SLC6A3MEN1KMT2AMAPK14 | |
| SCHEMBL12365683 | 0.84 | BRD4 (0.39) | HSD17B3SLC6A3MEN1KMT2AMAPK14 | |
| SCHEMBL12389888 | 0.84 | MEN1 (0.45) | HSD17B3SLC6A3MEN1KMT2AMAPK14 | |
| SCHEMBL12365301 | 0.84 | MAPK14 (0.43) | HSD17B3SLC6A3MEN1KMT2AMAPK14 | |
| SCHEMBL12365758 | 0.82 | MEN1 (0.40) | HSD17B3SLC6A3MEN1KMT2AMAPK14 | |
| SCHEMBL12365832 | 0.82 | MAPK14 (0.44) | HSD17B3MEN1KMT2AMAPK14NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110207729-A1 | BICYCLIC ACYLGUANIDINE DERIVATIVE | ASTELLAS PHARMA INC. (JP) | 2011-08-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110207729-A1 | BICYCLIC ACYLGUANIDINE DERIVATIVE | HTR5A, HTR2A, HTR1E | HSD17B3 487/4885SLC6A3 137/4885MEN1 4480/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.