Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | ACHE | P22303 | 2/20 | 0.39 |
| ▸ | CA1 | P00915 | 1/20 | 0.37 |
| ▸ | CA2 | P00918 | 1/20 | 0.37 |
| ▸ | CA7 | P43166 | 1/20 | 0.37 |
| ▸ | CA9 | Q16790 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
| ▸ | CASR | P41180 | 1/20 | 0.31 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.31 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.31 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.30 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.30 |
| ▸ | NPC1 | O15118 | 1/20 | 0.30 |
| ▸ | RAB9A | P51151 | 1/20 | 0.30 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.30 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.30 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12667246 | 0.76 | ALDH1A1 (0.41) | TSHRCA1CA2CA7CA9 | |
| SCHEMBL1188527 | 0.75 | TSHR (0.47) | TSHRACHECA1CA2CA7 | |
| SCHEMBL20231791 | 0.73 | TSHR (0.45) | TSHRACHECA1CA2CA7 | |
| SCHEMBL4433607 | 0.72 | PTGS2 (0.37) | ALDH1A1HSD17B10TDP1CYP2A6 | |
| SCHEMBL5187678 | 0.71 | TSHR (0.43) | TSHRACHECA1CA2CA7 | |
| SCHEMBL230855 | 0.71 | TSHR (0.43) | TSHRACHECA1CA2CA7 | |
| SCHEMBL29080964 | 0.71 | TSHR (0.43) | TSHRACHECA1CA2CA7 | |
| Potassium SCHEMBL6755124 | 0.70 | TSHR (0.41) | TSHRACHECA1CA2CA7 | |
| Hydrochloric Acid SCHEMBL11774243 | 0.70 | TSHR (0.41) | TSHRACHECA1CA2CA7 | |
| SCHEMBL19895699 | 0.70 | TSHR (0.41) | TSHRACHECA1CA2CA7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130267714-A1 | BIDENTATE CHIRAL LIGANDS FOR USE IN CATALYTIC ASYMMETRIC ADDITION REACTIONS | SOLVIAS AG (CH) | 2013-10-10 | — | — | US | disclosed |
| US-8450501-B2 | Bidentate chiral ligands for use in catalytic asymmetric addition reactions | SOLVIAS AG (CH) | 2013-05-28 | — | — | US | disclosed |
| US-8415488-B2 | Bidentate secondary phosphine oxide chiral ligands for use in asymmetric addition reactions | SOLVIAS AG (CH) | 2013-04-09 | — | — | US | disclosed |
| US-8008529-B2 | Chiral ligands used in transition metal catalysts for asymmetric addition reactions especially hydrogenation | SOLVIAS AG (CH) | 2011-08-30 | — | — | US | disclosed |
| US-20110118482-A1 | BIDENTATE CHIRAL LIGANDS FOR USE IN CATALYTIC ASYMMETRIC ADDITION REACTIONS | SOLVIAS AG | 2011-05-19 | — | — | US | disclosed |
| US-20110098485-A1 | BIDENTATE SECONDARY PHOSPHINE OXIDE CHIRAL LIGANDS FOR USE IN ASYMMETRIC ADDITION REACTIONS | SOLVIAS AG (CH) | 2011-04-28 | — | — | US | disclosed |
| US-20090171114-A1 | Chiral Ligands Used in Transition Metal Catysts for Asymmetric Addition Reactions Especially Hydrogenation | SOLVIAS AG (CH) | 2009-07-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110098485-A1 | BIDENTATE SECONDARY PHOSPHINE OXIDE CHIRAL LIGANDS FOR USE IN ASYMMETRIC ADDITION REACTIONS | H1-2, PHOSPHO1, H1-0 | TSHR 1741/4885ACHE 4433/4885CA1 173/4885 |
| US-20090171114-A1 | Chiral Ligands Used in Transition Metal Catysts for Asymmetric Addition Reactions Especially Hydrogenation | HRH3, HRH4, HRH1 | TSHR 1571/4885ACHE 2822/4885CA1 135/4885 |
| US-20130267714-A1 | BIDENTATE CHIRAL LIGANDS FOR USE IN CATALYTIC ASYMMETRIC ADDITION REACTIONS | C1R, PNISR, CBR1 | TSHR 512/4885ACHE 1920/4885CA1 2000/4885 |
| US-20110118482-A1 | BIDENTATE CHIRAL LIGANDS FOR USE IN CATALYTIC ASYMMETRIC ADDITION REACTIONS | H1-2, H1-0, C1R | TSHR 1127/4885ACHE 4187/4885CA1 349/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.