Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HKDC1 | Q2TB90 | 1/20 | 0.59 |
| ▸ | TSHR | P16473 | 3/20 | 0.50 |
| ▸ | GPR35 | Q9HC97 | 4/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.45 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.42 |
| ▸ | S100A4 | P26447 | 2/20 | 0.41 |
| ▸ | PTPRC | P08575 | 1/20 | 0.41 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.41 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.41 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.41 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.41 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.41 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.41 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.41 |
| ▸ | HPRT1 | P00492 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29435119 | 0.89 | HKDC1 (0.65) | HKDC1TSHRGPR35ALDH1A1KDM4E | |
| SCHEMBL74588 | 0.89 | HKDC1 (0.65) | HKDC1TSHRGPR35ALDH1A1KDM4E | |
| SCHEMBL6541857 | 0.80 | HKDC1 (0.56) | HKDC1GPR35ALDH1A1KDM4EMAPT | |
| SCHEMBL12520177 | 0.80 | HKDC1 (0.52) | HKDC1TSHRGPR35ALDH1A1HSP90AA1 | |
| SCHEMBL7522376 | 0.80 | HKDC1 (0.56) | HKDC1GPR35ALDH1A1HSP90AA1KDM4E | |
| SCHEMBL3207925 | 0.79 | HKDC1 (0.55) | HKDC1GPR35ALDH1A1HSP90AA1KDM4E | |
| SCHEMBL11518981 | 0.79 | S100A4 (0.61) | HKDC1TSHRGPR35ALDH1A1HSP90AA1 | |
| SCHEMBL6378793 | 0.79 | S100A4 (0.69) | HKDC1TSHRALDH1A1MAPTCYP3A4 | |
| SCHEMBL12111229 | 0.79 | S100A4 (0.55) | HKDC1TSHRGPR35ALDH1A1HSP90AA1 | |
| SCHEMBL715432 | 0.78 | HKDC1 (0.53) | HKDC1TSHRGPR35ALDH1A1HSP90AA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8779138-B2 | Camptothecin derivatives as chemoradiosensitizing agents | Sutter West Bay Hospital (US) | 2014-07-15 | — | — | US | disclosed |
| US-20110184009-A1 | CAMPTOTHECIN DERIVATIVES AS CHEMORADIOSENSITIZING AGENTS | SUTTER WEST BAY HOSPITALS, DBA CALIFORNIA PACIFIC MEDICAL CENTER | 2011-07-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110184009-A1 | CAMPTOTHECIN DERIVATIVES AS CHEMORADIOSENSITIZING AGENTS | ERCC2, CHEK1, ERCC4 | HKDC1 1914/4885TSHR 2490/4885GPR35 3606/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.