Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR3C1 | P04150 | 8/20 | 0.73 |
| ▸ | CYP3A4 | P08684 | 7/20 | 0.73 |
| ▸ | PGR | P06401 | 6/20 | 0.73 |
| ▸ | ABCB11 | O95342 | 4/20 | 0.73 |
| ▸ | LMNA | P02545 | 4/20 | 0.73 |
| ▸ | AR | P10275 | 3/20 | 0.73 |
| ▸ | ADORA3 | P0DMS8 | 3/20 | 0.73 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.73 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.73 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.73 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.73 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.73 |
| ▸ | SLCO1B3 | Q9NPD5 | 1/20 | 0.73 |
| ▸ | SLCO1B1 | Q9Y6L6 | 1/20 | 0.73 |
| ▸ | CNR1 | P21554 | 2/20 | 0.55 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.55 |
| ▸ | USP2 | O75604 | 4/20 | 0.54 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.54 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.54 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13950974 | 0.88 | NR3C1 (0.79) | NR3C1CYP3A4PGRABCB11LMNA | |
| SCHEMBL12397410 | 0.87 | NR3C1 (0.76) | NR3C1CYP3A4PGRABCB11LMNA | |
| SCHEMBL12396774 | 0.87 | NR3C1 (0.68) | NR3C1CYP3A4PGRABCB11LMNA | |
| SCHEMBL12396688 | 0.86 | NR3C1 (0.85) | NR3C1CYP3A4PGRABCB11LMNA | |
| SCHEMBL4208384 | 0.86 | NR3C1 (0.75) | NR3C1CYP3A4PGRABCB11LMNA | |
| SCHEMBL13928683 | 0.86 | NR3C1 (0.75) | NR3C1CYP3A4PGRABCB11LMNA | |
| SCHEMBL12398451 | 0.86 | NR3C1 (0.70) | NR3C1CYP3A4PGRABCB11LMNA | |
| Mometasone Furoate SCHEMBL25382496 | 0.85 | CYP3A4 (1.00) | NR3C1CYP3A4PGRABCB11LMNA | |
| Mometasone Furoate SCHEMBL4568 | 0.85 | CYP3A4 (1.00) | NR3C1CYP3A4PGRABCB11LMNA | |
| Mometasone Furoate SCHEMBL7436523 | 0.85 | CYP3A4 (1.00) | NR3C1CYP3A4PGRABCB11LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8524697-B2 | C20-C21 substituted glucocorticoid receptor agonists | MERCK SHARP & DOHME CORP. (US) | 2013-09-03 | — | — | US | disclosed |
| US-8524697-B2 | C20-C21 substituted glucocorticoid receptor agonists | MERCK SHARP & DOHME CORP. (US) | 2013-09-03 | — | — | US | disclosed |
| US-20110182828-A1 | C20-C21 SUBSTITUTED GLUCOCORTICOID RECEPTOR AGONISTS | SCHERING CORPORATION (US) | 2011-07-28 | — | — | US | disclosed |
| US-20110182828-A1 | C20-C21 SUBSTITUTED GLUCOCORTICOID RECEPTOR AGONISTS | SCHERING CORPORATION (US) | 2011-07-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110182828-A1 | C20-C21 SUBSTITUTED GLUCOCORTICOID RECEPTOR AGONISTS | NR3C1, MC2R, NR3C2 | NR3C1 1/4885CYP3A4 342/4885PGR 318/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.