⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12398389 | 0.78 | — | — | |
| SCHEMBL23196397 | 0.73 | — | — | |
| SCHEMBL11947207 | 0.73 | DGAT1 (0.30) | — | |
| SCHEMBL21024040 | 0.72 | CREBBP (0.39) | — | |
| SCHEMBL18806102 | 0.69 | — | — | |
| SCHEMBL26424498 | 0.68 | GRM4 (0.30) | — | |
| SCHEMBL22201885 | 0.68 | SYK (0.39) | — | |
| SCHEMBL22201891 | 0.68 | MAPK1 (0.35) | — | |
| SCHEMBL22941285 | 0.67 | ALDH1A1 (0.53) | — | |
| SCHEMBL24198307 | 0.67 | TDO2 (0.34) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230130909-A1 | HPK1 INHIBITOR, PREPARATION METHOD THEREFOR AND USE THEREOF | Wigen Biomedicine Technology (shanghai) Co., Ltd. (CN) | 2023-04-27 | — | — | US | disclosed |
| US-20210100802-A1 | HETEROCYCLIC COMPOUNDS AND USES AS ANTICANCER AGENTS | ACEA Therapeutics, Inc. (US) | 2021-04-08 | — | — | US | disclosed |
| US-10799504-B2 | Heterocyclic compounds and uses as anticancer agents | ACEA Therapeutics, Inc. (US) | 2020-10-13 | — | — | US | disclosed |
| US-9879028-B2 | Compounds that modulate EGFR activity and methods for treating or preventing conditions therewith | Gatekeeper Pharmaceuticals, Inc. (US) | 2018-01-30 | — | — | US | disclosed |
| US-20110207736-A1 | COMPOUNDS THAT MODULATE EGFR ACTIVITY AND METHODS FOR TREATING OR PREVENTING CONDITIONS THEREWITH | Gatekeeper Pharmaceuticals, Inc. | 2011-08-25 | — | — | US | disclosed |