Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.59 |
| ▸ | MEN1 | O00255 | 7/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.59 |
| ▸ | RAB9A | P51151 | 3/20 | 0.59 |
| ▸ | POLB | P06746 | 3/20 | 0.59 |
| ▸ | HPGD | P15428 | 3/20 | 0.59 |
| ▸ | NPC1 | O15118 | 2/20 | 0.59 |
| ▸ | MAPT | P10636 | 2/20 | 0.59 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.59 |
| ▸ | IP6K1 | Q92551 | 5/20 | 0.58 |
| ▸ | IP6K3 | Q96PC2 | 4/20 | 0.58 |
| ▸ | IP6K2 | Q9UHH9 | 4/20 | 0.58 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.58 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.49 |
| ▸ | GFER | P55789 | 1/20 | 0.46 |
| ▸ | PIM1 | P11309 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12401812 | 0.87 | ALDH1A1 (0.59) | ALDH1A1MEN1KMT2AKDM4ESMN1; SMN2 | |
| SCHEMBL14943768 | 0.84 | ALDH1A1 (0.69) | ALDH1A1MEN1KMT2AKDM4ESMN1; SMN2 | |
| SCHEMBL13208416 | 0.77 | ALDH1A1 (0.57) | ALDH1A1MEN1KMT2AKDM4ESMN1; SMN2 | |
| SCHEMBL12330213 | 0.75 | ALDH1A1 (0.63) | ALDH1A1MEN1KMT2AKDM4ESMN1; SMN2 | |
| SCHEMBL6199027 | 0.75 | KDM4E (1.00) | ALDH1A1MEN1KMT2AKDM4ESMN1; SMN2 | |
| SCHEMBL10396461 | 0.74 | ALDH1A1 (0.66) | ALDH1A1MEN1KMT2AKDM4ESMN1; SMN2 | |
| SCHEMBL10397089 | 0.74 | ALDH1A1 (0.56) | ALDH1A1MEN1KMT2AKDM4ESMN1; SMN2 | |
| SCHEMBL21305373 | 0.74 | LRRK2 (0.39) | ALDH1A1MEN1KMT2ASMN1; SMN2RAB9A | |
| SCHEMBL15560352 | 0.71 | PIM1 (0.47) | ALDH1A1MEN1KMT2AKDM4ESMN1; SMN2 | |
| SCHEMBL21305159 | 0.68 | LRRK2 (0.35) | ALDH1A1RAB9AHPGDNPC1IP6K1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8440706-B2 | Inhibitors of serine proteases | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2013-05-14 | — | — | US | disclosed |
| US-8372873-B2 | Inhibitors of serine proteases | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2013-02-12 | — | — | US | disclosed |
| US-20110182856-A1 | INHIBITORS OF SERINE PROTEASES | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2011-07-28 | — | — | US | disclosed |
| US-7985762-B2 | Inhibitors of serine proteases | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2011-07-26 | — | — | US | disclosed |
| US-20110165120-A1 | INHIBITORS OF SERINE PROTEASES | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2011-07-07 | — | — | US | disclosed |
| US-7964624-B1 | Inhibitors of serine proteases | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2011-06-21 | — | — | US | disclosed |
| US-20070179167-A1 | Inhibitors of serine proteases | VERTEX PHARMACEUTICALS INCORPORATED | 2007-08-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110165120-A1 | INHIBITORS OF SERINE PROTEASES | PRSS1, PRSS3, PRSS2 | ALDH1A1 1374/4885MEN1 2930/4885KMT2A 3222/4885 |
| US-20070179167-A1 | Inhibitors of serine proteases | PRSS1, PRSS3, PRSS2 | ALDH1A1 1374/4885MEN1 2930/4885KMT2A 3222/4885 |
| US-20110182856-A1 | INHIBITORS OF SERINE PROTEASES | PRSS1, SPINT2, PRSS2 | ALDH1A1 1255/4885MEN1 3395/4885KMT2A 2779/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.