Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX15 | P16050 | 7/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.52 |
| ▸ | MAPT | P10636 | 2/20 | 0.52 |
| ▸ | ATP2A2 | P16615 | 1/20 | 0.52 |
| ▸ | ATP2A3 | Q93084 | 1/20 | 0.52 |
| ▸ | CYP2C9 | P11712 | 6/20 | 0.47 |
| ▸ | TP53 | P04637 | 5/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 5/20 | 0.47 |
| ▸ | HIF1A | Q16665 | 4/20 | 0.47 |
| ▸ | LMNA | P02545 | 4/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.40 |
| ▸ | TYR | P14679 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.39 |
| ▸ | MIF | P14174 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16117993 | 0.85 | ALOX15 (0.52) | ALOX15ALDH1A1SMN1; SMN2CYP1A2KDM4E | |
| SCHEMBL16736921 | 0.81 | ALOX15 (0.48) | ALOX15ALDH1A1SMN1; SMN2CYP1A2KDM4E | |
| SCHEMBL12401839 | 0.81 | CYP2C9 (0.43) | ALOX15ALDH1A1SMN1; SMN2CYP1A2KDM4E | |
| SCHEMBL16117670 | 0.79 | ALDH1A1 (0.67) | ALOX15ALDH1A1SMN1; SMN2CYP1A2KDM4E | |
| SCHEMBL16736743 | 0.79 | ALOX15 (0.45) | ALOX15ALDH1A1SMN1; SMN2CYP1A2KDM4E | |
| SCHEMBL11007029 | 0.78 | ALDH1A1 (0.65) | ALOX15ALDH1A1SMN1; SMN2CYP1A2KDM4E | |
| SCHEMBL11434411 | 0.78 | ALDH1A1 (0.58) | ALOX15ALDH1A1SMN1; SMN2CYP1A2KDM4E | |
| SCHEMBL16736702 | 0.77 | ALOX15 (0.71) | ALOX15ALDH1A1SMN1; SMN2CYP1A2KDM4E | |
| SCHEMBL16117679 | 0.77 | ALOX15 (0.52) | ALOX15ALDH1A1SMN1; SMN2CYP1A2KDM4E | |
| SCHEMBL12401842 | 0.77 | HTR2A (0.50) | ALOX15ALDH1A1SMN1; SMN2CYP1A2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8372873-B2 | Inhibitors of serine proteases | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2013-02-12 | — | — | US | disclosed |
| US-20110182856-A1 | INHIBITORS OF SERINE PROTEASES | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2011-07-28 | — | — | US | disclosed |
| US-7964624-B1 | Inhibitors of serine proteases | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2011-06-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110182856-A1 | INHIBITORS OF SERINE PROTEASES | PRSS1, SPINT2, PRSS2 | ALOX15 3225/4885ALDH1A1 1255/4885SMN1; SMN2 2156/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.