SCHEMBL12402912

SCHEMBL12402912

c1ccc(-c2cc3c(cc2-c2ccccn2)c2cc4c5cc(-c6ccccn6)c(-c6ccccn6)cc5c4cc32)nc1

nearest known ligand 0.59

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ KDM4E B2RXH2 8/20 0.59
▸ LMNA P02545 3/20 0.59
▸ CCR1 P32246 3/20 0.59
▸ CCR5 P51681 3/20 0.59
▸ CCR8 P51685 3/20 0.59
▸ CYP1A2 P05177 1/20 0.59
▸ POLB P06746 1/20 0.59
▸ METAP1 P53582 1/20 0.59
▸ BLM P54132 1/20 0.59
▸ HIF1A Q16665 1/20 0.59
▸ DOHH Q9BU89 1/20 0.59
▸ P4HTM Q9NXG6 1/20 0.59
▸ NPC1 O15118 6/20 0.50
▸ TP53 P04637 4/20 0.50
▸ RAB9A P51151 4/20 0.50
▸ ALOX15 P16050 3/20 0.50
▸ SMN1; SMN2 Q16637 3/20 0.50
▸ L3MBTL1 Q9Y468 3/20 0.50
▸ TDP1 Q9NUW8 2/20 0.50
▸ HTT P42858 2/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL13910993 0.87 KDM4E (0.68) KDM4ELMNACCR1CCR5CCR8
SCHEMBL29725567 0.87 KDM4E (0.68) KDM4ELMNACCR1CCR5CCR8
SCHEMBL12402907 0.86 KDM4E (0.69) KDM4ELMNACCR1CCR5CCR8
SCHEMBL26259950 0.80 KDM4E (0.65) KDM4ELMNACCR1CCR5CCR8
SCHEMBL858806 0.79 KDM4E (0.72) KDM4ELMNACCR1CCR5CCR8
SCHEMBL14981147 0.78 KDM4E (0.62) KDM4ELMNACCR1CCR5CCR8
SCHEMBL13295249 0.78 KDM4E (0.62) KDM4ELMNACCR1CCR5CCR8
SCHEMBL26259997 0.78 KDM4E (0.62) KDM4ELMNACCR1CCR5CCR8
SCHEMBL10025406 0.77 KDM4E (0.54) KDM4ELMNACCR1CCR5CCR8
SCHEMBL11965541 0.77 KDM4E (0.68) KDM4ELMNACCR1CCR5CCR8

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1867623-B1 TERPHENYLENE DERIVATIVES, TETRAHALOTERPHENYL DERIVATIVES AND PROCESSES FOR THE PRODUCTION OF BOTH TOSOH CORP (JP) 2017-05-10 — — EP disclosed
US-7985885-B2 Terphenylene derivative, tetrahaloterphenyl derivative, and processes for producing both TOSOH CORPORATION (JP) 2011-07-26 — — US disclosed
US-7985885-B2 Terphenylene derivative, tetrahaloterphenyl derivative, and processes for producing both TOSOH CORPORATION (JP) 2011-07-26 — — US disclosed
US-20090023957-A1 TERPHENYLENE DERIVATIVE, TETRAHALOTERPHENYL DERIVATIVE, AND PROCESSES FOR PRODUCING BOTH TOSOH CORPORATION (JP) 2009-01-22 — — US disclosed
US-20090023957-A1 TERPHENYLENE DERIVATIVE, TETRAHALOTERPHENYL DERIVATIVE, AND PROCESSES FOR PRODUCING BOTH TOSOH CORPORATION (JP) 2009-01-22 — — US disclosed
EP-1867623-A1 TERPHENYLENE DERIVATIVES, TETRAHALOTERPHENYL DERIVATIVES AND PROCESSES FOR THE PRODUCTION OF BOTH Tosoh Corporation (JP) 2007-12-19 — — EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090023957-A1 TERPHENYLENE DERIVATIVE, TETRAHALOTERPHENYL DERIVATIVE, AND PROCESSES FOR PRODUCING BOTH TERT, TLN1, TTI1 KDM4E 353/4885LMNA 2268/4885CCR1 2856/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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