Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DCPS | Q96C86 | 16/20 | 0.73 |
| ▸ | DHFR | P00374 | 5/20 | 0.69 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1154903 | 0.90 | DCPS (0.83) | DCPSDHFRCYP2D6 | |
| SCHEMBL2166220 | 0.88 | DHFR (0.75) | DCPSDHFRCYP2D6 | |
| SCHEMBL1155035 | 0.85 | DCPS (0.79) | DCPSDHFRCYP2D6 | |
| SCHEMBL1154891 | 0.85 | DCPS (0.79) | DCPSDHFRCYP2D6 | |
| SCHEMBL2164866 | 0.84 | DCPS (0.75) | DCPSDHFRCYP2D6 | |
| SCHEMBL2165182 | 0.84 | DCPS (0.64) | DCPSDHFRCYP2D6 | |
| SCHEMBL2166490 | 0.84 | DCPS (0.75) | DCPSDHFRCYP2D6 | |
| SCHEMBL2166555 | 0.84 | DCPS (1.00) | DCPSDHFRCYP2D6 | |
| SCHEMBL1154212 | 0.84 | DCPS (0.77) | DCPSDHFRCYP2D6 | |
| SCHEMBL1155228 | 0.82 | DCPS (0.74) | DCPSDHFRCYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7985755-B2 | 2,4-diaminoquinazolines for spinal muscular atrophy | FAMILIES OF SPINAL MUSCULAR ATROPHY (US) | 2011-07-26 | — | — | US | disclosed |
| US-20090042900-A1 | 2,4-DIAMINOQUINAZOLINES FOR SPINAL MUSCULAR ATROPHY | DECODE CHEMISTRY, INC. (US) | 2009-02-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090042900-A1 | 2,4-DIAMINOQUINAZOLINES FOR SPINAL MUSCULAR ATROPHY | SMN1; SMN2, MUSK, MYT1 | DCPS 1366/4885DHFR 1446/4885CYP2D6 3869/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.