SCHEMBL12410754

SCHEMBL12410754

CN1CCc2cc(N3C[C@H](CNC(=O)c4ccc(Cl)s4)OC3=O)c(Cl)cc2C1

nearest known ligand 0.61

Predicted protein targets (top 1)

geneUniProtsupporting neighboursconfidence
F10 P00742 20/20 0.61

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2183278 0.97 F10 (0.64) F10
SCHEMBL8045834 0.88 F10 (0.67) F10
SCHEMBL2182585 0.87 F10 (0.68) F10
SCHEMBL2182549 0.87 F10 (0.49) F10
SCHEMBL12410715 0.86 F10 (0.71) F10
SCHEMBL12410757 0.83 F10 (0.61) F10
SCHEMBL2184604 0.78 F10 (0.63) F10
SCHEMBL2184602 0.78 F10 (0.63) F10
SCHEMBL2183362 0.78 F10 (0.63) F10
SCHEMBL2183364 0.78 F10 (0.63) F10

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8741890-B2 Substituted amides, manufacturing and use thereof as medicaments BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) 2014-06-03 US disclosed
US-8741890-B2 Substituted amides, manufacturing and use thereof as medicaments BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) 2014-06-03 US disclosed
US-20110166125-A1 SUBSTITUTED AMIDES, MANUFACTURING AND USE THEREOF AS MEDICAMENTS BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) 2011-07-07 US disclosed
US-20110166125-A1 SUBSTITUTED AMIDES, MANUFACTURING AND USE THEREOF AS MEDICAMENTS BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) 2011-07-07 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110166125-A1 SUBSTITUTED AMIDES, MANUFACTURING AND USE THEREOF AS MEDICAMENTS ARG1, P4HA1, ASS1 F10 981/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.