Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | CNR1 | P21554 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23310432 | 0.77 | HDAC4 (0.33) | CNR1 | |
| SCHEMBL12169409 | 0.69 | TSHR (0.58) | TSHRALDH1A1 | |
| SCHEMBL12217144 | 0.69 | NPC1 (0.34) | ALDH1A1 | |
| SCHEMBL12401758 | 0.69 | HDAC4 (0.35) | TSHR | |
| SCHEMBL8930686 | 0.69 | TSHR (0.56) | TSHRALDH1A1 | |
| SCHEMBL9719308 | 0.68 | TSHR (0.62) | TSHRALDH1A1 | |
| SCHEMBL12401786 | 0.67 | PPARA (0.34) | — | |
| SCHEMBL8930662 | 0.66 | TSHR (0.59) | TSHRALDH1A1 | |
| SCHEMBL7519328 | 0.66 | TSHR (1.00) | TSHR | |
| SCHEMBL11021936 | 0.66 | AHR (0.45) | TSHRALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110165120-A1 | INHIBITORS OF SERINE PROTEASES | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2011-07-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110165120-A1 | INHIBITORS OF SERINE PROTEASES | PRSS1, PRSS3, PRSS2 | TSHR 4684/4885ALDH1A1 1374/4885CNR1 4337/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.