Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 4/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | CD44 | P16070 | 1/20 | 0.32 |
| ▸ | ADRB2 | P07550 | 3/20 | 0.32 |
| ▸ | ABL1 | P00519 | 1/20 | 0.32 |
| ▸ | KDR | P35968 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.31 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.31 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.31 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.31 |
| ▸ | EGLN2 | Q96KS0 | 1/20 | 0.31 |
| ▸ | UHRF1 | Q96T88 | 1/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | TTR | P02766 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16320147 | 0.94 | TSHR (0.37) | TSHRCYP3A4MAPK1ALDH1A1KDM4E | |
| SCHEMBL5287616 | 0.87 | TSHR (0.48) | TSHRCYP3A4MAPK1ALDH1A1KDM4E | |
| SCHEMBL28863952 | 0.82 | POLB (0.38) | TSHRCYP3A4MAPK1ALDH1A1KDM4E | |
| SCHEMBL1343876 | 0.80 | TSHR (0.39) | TSHRALDH1A1EGLN2MEN1TTR | |
| SCHEMBL11689061 | 0.80 | HTT (0.36) | TSHRCYP3A4MAPK1ALDH1A1KDM4E | |
| SCHEMBL30702008 | 0.80 | TSHR (0.39) | TSHRALDH1A1EGLN2MEN1TTR | |
| SCHEMBL7024058 | 0.80 | TSHR (0.52) | TSHRCYP3A4MAPK1ALDH1A1KDM4E | |
| SCHEMBL13147636 | 0.78 | TSHR (0.48) | TSHRCYP3A4MAPK1ALDH1A1KDM4E | |
| SCHEMBL1343737 | 0.78 | TSHR (0.41) | TSHRALDH1A1TDP1DYRK1AMEN1 | |
| SCHEMBL1771090 | 0.77 | TSHR (0.42) | TSHRCYP3A4MAPK1ALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8841311-B2 | Sulphone-substituted quinazoline derivatives as immuno-modulators, their preparation and use as medicaments | BAYER INTELLECTUAL PROPERTY GMBH (DE) | 2014-09-23 | — | — | US | disclosed |
| US-20110166168-A1 | Sulphone-substituted quinazoline derivatives as immuno-modulators, their preparation and use as medicaments | BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) | 2011-07-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110166168-A1 | Sulphone-substituted quinazoline derivatives as immuno-modulators, their preparation and use as medicaments | TPMT, IFNG, HLA-DRB1 | TSHR 3982/4885CYP3A4 221/4885MAPK1 2766/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.