Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 7/20 | 0.73 |
| ▸ | CA1 | P00915 | 6/20 | 0.73 |
| ▸ | PTGS2 | P35354 | 12/20 | 0.65 |
| ▸ | PTGS1 | P23219 | 5/20 | 0.65 |
| ▸ | CA9 | Q16790 | 5/20 | 0.65 |
| ▸ | CA12 | O43570 | 3/20 | 0.65 |
| ▸ | CA7 | P43166 | 2/20 | 0.55 |
| ▸ | HPGD | P15428 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12416919 | 0.90 | CA2 (0.77) | CA2CA1PTGS2PTGS1CA9 | |
| SCHEMBL18719807 | 0.88 | HPGD (0.58) | CA2CA1PTGS2PTGS1CA9 | |
| SCHEMBL12416826 | 0.82 | CA2 (0.72) | CA2CA1PTGS2PTGS1CA9 | |
| SCHEMBL1517619 | 0.79 | PTGS2 (1.00) | CA2CA1PTGS2PTGS1CA9 | |
| SCHEMBL5311504 | 0.79 | PTGS2 (1.00) | CA2CA1PTGS2PTGS1CA9 | |
| SCHEMBL5308961 | 0.79 | PTGS2 (1.00) | CA2CA1PTGS2PTGS1CA9 | |
| SCHEMBL5311501 | 0.79 | PTGS2 (1.00) | CA2CA1PTGS2PTGS1CA9 | |
| SCHEMBL15896224 | 0.77 | CA12 (0.56) | CA2CA1PTGS2PTGS1CA9 | |
| SCHEMBL18719808 | 0.77 | CA2 (0.60) | CA2CA1PTGS2PTGS1CA9 | |
| SCHEMBL12416992 | 0.76 | PTGS2 (0.64) | CA2CA1PTGS2PTGS1CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10471028-B2 | Small molecule efflux pump inhibitors | UNIVERSITY OF ROCHESTER (US) | 2019-11-12 | — | — | US | disclosed |
| US-20170100414-A1 | SMALL MOLECULE EFFLUX PUMP INHIBITORS | UNIVERSITY OF ROCHESTER (US) | 2017-04-13 | — | — | US | disclosed |
| US-20170100414-A1 | SMALL MOLECULE EFFLUX PUMP INHIBITORS | UNIVERSITY OF ROCHESTER (US) | 2017-04-13 | — | — | US | disclosed |
| US-20110172234-A1 | METHODS AND COMPOSITIONS OF TRAIL-DEATH RECEPTOR AGONISTS/ACTIVATORS | THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM (US) | 2011-07-14 | — | — | US | disclosed |
| US-20110172234-A1 | METHODS AND COMPOSITIONS OF TRAIL-DEATH RECEPTOR AGONISTS/ACTIVATORS | THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM (US) | 2011-07-14 | — | — | US | disclosed |
| US-7915245-B2 | Using small molecules as binding ligands, for the recruitment of Fas-associated death domain protein, activation of death-inducing signaling complex, caspase-8, and apoptosis in malignant cells; anticarcinogens, antitumor agents; enhanced cellular differentiation, minimizing cytolysis to healthy cells | THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM (US) | 2011-03-29 | — | — | US | disclosed |
| US-7915245-B2 | Using small molecules as binding ligands, for the recruitment of Fas-associated death domain protein, activation of death-inducing signaling complex, caspase-8, and apoptosis in malignant cells; anticarcinogens, antitumor agents; enhanced cellular differentiation, minimizing cytolysis to healthy cells | THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM (US) | 2011-03-29 | — | — | US | disclosed |
| US-20080214547-A1 | METHODS AND COMPOSITIONS OF TRAIL-DEATH RECEPTOR AGONISTS/ACTIVATORS | UNIVERSITY OF MARYLAND, BALTIMORE | 2008-09-04 | — | — | US | disclosed |
| US-20080214547-A1 | METHODS AND COMPOSITIONS OF TRAIL-DEATH RECEPTOR AGONISTS/ACTIVATORS | UNIVERSITY OF MARYLAND, BALTIMORE | 2008-09-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080214547-A1 | METHODS AND COMPOSITIONS OF TRAIL-DEATH RECEPTOR AGONISTS/ACTIVATORS | BID, BAD, MCL1 | CA2 2958/4885CA1 1082/4885PTGS2 1147/4885 |
| US-10471028-B2 | Small molecule efflux pump inhibitors | ABCB11, ABCB1, ABCC1 | CA2 2754/4885CA1 4863/4885PTGS2 469/4885 |
| US-20110172234-A1 | METHODS AND COMPOSITIONS OF TRAIL-DEATH RECEPTOR AGONISTS/ACTIVATORS | BID, BAD, MCL1 | CA2 2958/4885CA1 1082/4885PTGS2 1147/4885 |
| US-20170100414-A1 | SMALL MOLECULE EFFLUX PUMP INHIBITORS | ABCB11, ABCB1, ABCC1 | CA2 2754/4885CA1 4863/4885PTGS2 469/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.