Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.52 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.52 |
| ▸ | SIRT5 | Q9NXA8 | 2/20 | 0.47 |
| ▸ | CA1 | P00915 | 2/20 | 0.44 |
| ▸ | CA2 | P00918 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | THRB | P10828 | 1/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.44 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.44 |
| ▸ | THPO | P40225 | 1/20 | 0.44 |
| ▸ | RECQL | P46063 | 1/20 | 0.44 |
| ▸ | BLM | P54132 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | TLR2 | O60603 | 2/20 | 0.43 |
| ▸ | FURIN | P09958 | 8/20 | 0.42 |
| ▸ | GNPAT | O15228 | 1/20 | 0.41 |
| ▸ | CPA1 | P15085 | 1/20 | 0.40 |
| ▸ | CPA2 | P48052 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18715483 | 0.92 | TLR2 (0.48) | SIRT6SIRT1SIRT5CA1CA2 | |
| SCHEMBL18708300 | 0.92 | TLR2 (0.48) | SIRT6SIRT1SIRT5CA1CA2 | |
| SCHEMBL4807610 | 0.92 | FURIN (0.51) | SIRT6SIRT1SIRT5CA1CA2 | |
| SCHEMBL11299637 | 0.91 | SIRT6 (0.45) | SIRT6SIRT1SIRT5CA1CA2 | |
| SCHEMBL16993754 | 0.91 | SIRT6 (0.45) | SIRT6SIRT1SIRT5CA1CA2 | |
| SCHEMBL29370896 | 0.87 | KDM4E (0.57) | SIRT6SIRT1CA1CA2KDM4E | |
| SCHEMBL931282 | 0.86 | KDM4E (0.57) | SIRT6SIRT1SIRT5CA1KDM4E | |
| SCHEMBL18098148 | 0.86 | KDM4E (0.57) | SIRT6SIRT1SIRT5CA1KDM4E | |
| SCHEMBL14601040 | 0.84 | SIRT5 (0.65) | SIRT6SIRT1SIRT5CA1CA2 | |
| SCHEMBL24514472 | 0.84 | KDM4E (0.50) | SIRT6SIRT1CA1CA2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8450097-B2 | Protein-proteophore complexes | ASCENDIS PHARMA GMBH (DE) | 2013-05-28 | — | — | US | disclosed |
| US-20110172390-A1 | Protein-Proteophore Complexes | ASCENDIS PHARMA A/S (DK) | 2011-07-14 | — | — | US | disclosed |
| US-7879588-B2 | Protein-proteophore complexes | ASCENDIS PHARMA A/S (DK) | 2011-02-01 | — | — | US | disclosed |
| US-7879588-B2 | Protein-proteophore complexes | ASCENDIS PHARMA A/S (DK) | 2011-02-01 | — | — | US | disclosed |
| US-20070020224-A1 | Protein-proteophore complexes | ASCENDIS PHARMA GMBH (DE) | 2007-01-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110172390-A1 | Protein-Proteophore Complexes | PSMG3, PSME1, PSMD11 | SIRT6 2392/4885SIRT1 2860/4885SIRT5 3870/4885 |
| US-20070020224-A1 | Protein-proteophore complexes | PSMG3, PSME1, PSMD11 | SIRT6 2392/4885SIRT1 2860/4885SIRT5 3870/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.