Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 1/20 | 0.63 |
| ▸ | CPA3 | P15088 | 3/20 | 0.62 |
| ▸ | FOLH1 | Q04609 | 3/20 | 0.58 |
| ▸ | CPA1 | P15085 | 7/20 | 0.56 |
| ▸ | CPB1 | P15086 | 1/20 | 0.56 |
| ▸ | CPB2 | Q96IY4 | 1/20 | 0.56 |
| ▸ | MME | P08473 | 1/20 | 0.53 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.51 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.51 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.51 |
| ▸ | NAALAD2 | Q9Y3Q0 | 1/20 | 0.47 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15247509 | 1.00 | CYP1A2 (0.63) | CYP1A2CPA3FOLH1CPA1CPB1 | |
| SCHEMBL12418044 | 0.90 | FOLH1 (0.64) | CYP1A2CPA3FOLH1CPA1CPB1 | |
| SCHEMBL15247515 | 0.90 | FOLH1 (0.64) | CYP1A2CPA3FOLH1CPA1CPB1 | |
| SCHEMBL23833831 | 0.89 | FOLH1 (0.62) | CYP1A2CPA3FOLH1CPA1CPB1 | |
| SCHEMBL20168324 | 0.85 | FOLH1 (0.61) | CYP1A2CPA3FOLH1CPA1 | |
| SCHEMBL20179140 | 0.85 | FOLH1 (0.61) | CYP1A2CPA3FOLH1CPA1 | |
| SCHEMBL29006953 | 0.84 | CYP1A2 (0.66) | CYP1A2CPA3FOLH1CPA1CPB1 | |
| SCHEMBL21577935 | 0.84 | CPA3 (0.44) | CYP1A2CPA3FOLH1CPA1CPB1 | |
| SCHEMBL21577999 | 0.84 | FOLH1 (0.68) | FOLH1 | |
| SCHEMBL20168567 | 0.84 | FOLH1 (0.68) | FOLH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11834515-B2 | Macrocyclic compounds as proteasome inhibitors | CORNELL UNIVERSITY (US) | 2023-12-05 | — | — | US | disclosed |
| US-8530456-B2 | Sonic hedgehog modulators | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2013-09-10 | — | — | US | disclosed |
| US-20110172233-A1 | SONIC HEDGEHOG MODULATORS | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 2011-07-14 | — | — | US | disclosed |
| US-20110172233-A1 | SONIC HEDGEHOG MODULATORS | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 2011-07-14 | — | — | US | disclosed |
| WO-2009132032-A2 | SONIC HEDGEHOG MODULATORS | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2009-10-29 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110172233-A1 | SONIC HEDGEHOG MODULATORS | SHH, GLI1, SMO | CYP1A2 4773/4885CPA3 3963/4885FOLH1 2179/4885 |
| US-11834515-B2 | Macrocyclic compounds as proteasome inhibitors | PSMB5, PSMB1, PSMB3 | CYP1A2 2638/4885CPA3 2549/4885FOLH1 4661/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.