Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B1 | P14061 | 10/20 | 0.63 |
| ▸ | MAPT | P10636 | 2/20 | 0.61 |
| ▸ | USP2 | O75604 | 1/20 | 0.61 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.61 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | STS | P08842 | 4/20 | 0.52 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.49 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | RECQL | P46063 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12379505 | 0.93 | USP2 (0.64) | HSD17B1MAPTUSP2MAPK1HRH3 | |
| SCHEMBL12379510 | 0.92 | HSD17B1 (0.76) | HSD17B1MAPTUSP2MAPK1HRH3 | |
| SCHEMBL2292483 | 0.88 | MAPT (0.63) | HSD17B1MAPTUSP2MAPK1HRH3 | |
| SCHEMBL12379440 | 0.88 | MAPT (0.63) | HSD17B1MAPTUSP2MAPK1HRH3 | |
| SCHEMBL12418958 | 0.86 | HSD17B1 (0.82) | HSD17B1MAPTMAPK1STSCYP3A4 | |
| SCHEMBL1977073 | 0.85 | MAPT (0.64) | HSD17B1MAPTUSP2MAPK1HRH3 | |
| SCHEMBL5849823 | 0.85 | MAPT (0.61) | HSD17B1MAPTUSP2MAPK1HRH3 | |
| SCHEMBL12419867 | 0.84 | USP2 (0.74) | HSD17B1MAPTUSP2MAPK1HRH3 | |
| SCHEMBL7518036 | 0.83 | MAPT (0.63) | HSD17B1MAPTUSP2MAPK1HRH3 | |
| SCHEMBL7124873 | 0.82 | HSD17B1 (0.64) | HSD17B1MAPTKDM4EALDH1A1STS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8003783-B2 | Steroid 17 beta -hydroxysteroid dehydrogenase inhibitors substituted with one or more oxime groups, especially aromatase inhibitors used in the treatment of endocrine-dependent tumors, especially breast cancer | STERIX LIMITED (GB) | 2011-08-23 | — | — | US | disclosed |
| EP-2336146-A1 | 17beta-hydroxysteroid dehydrogenase inhibitors | Sterix Limited (GB) | 2011-06-22 | — | — | EP | disclosed |