Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 1/20 | 0.62 |
| ▸ | HTT | P42858 | 1/20 | 0.56 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.56 |
| ▸ | RHOA | P61586 | 1/20 | 0.55 |
| ▸ | GRM3 | Q14832 | 3/20 | 0.54 |
| ▸ | EPHX2 | P34913 | 3/20 | 0.52 |
| ▸ | RAB9A | P51151 | 3/20 | 0.52 |
| ▸ | NPC1 | O15118 | 2/20 | 0.52 |
| ▸ | PROKR1 | Q8TCW9 | 1/20 | 0.50 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.49 |
| ▸ | MGLL | Q99685 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10723661 | 0.91 | GRM3 (0.56) | L3MBTL1GRM3EPHX2RAB9ANPC1 | |
| SCHEMBL10195743 | 0.86 | HPGD (0.61) | HPGDHTTL3MBTL1RHOAEPHX2 | |
| SCHEMBL12449544 | 0.84 | GRM3 (0.51) | HPGDL3MBTL1GRM3EPHX2RAB9A | |
| SCHEMBL9633280 | 0.84 | HPGD (0.64) | HPGDHTTL3MBTL1EPHX2HSD11B1 | |
| SCHEMBL10194851 | 0.84 | GRM3 (0.65) | L3MBTL1GRM3EPHX2RAB9ANPC1 | |
| SCHEMBL12965 | 0.83 | HPGD (0.67) | HPGDHTTL3MBTL1RHOAGRM3 | |
| SCHEMBL8053380 | 0.83 | HPGD (0.67) | HPGDHTTL3MBTL1RHOAEPHX2 | |
| SCHEMBL10724293 | 0.82 | GRM3 (0.68) | HPGDL3MBTL1GRM3EPHX2RAB9A | |
| SCHEMBL18082577 | 0.80 | HPGD (0.62) | HPGDHTTL3MBTL1RHOAEPHX2 | |
| SCHEMBL2667152 | 0.79 | HPGD (0.90) | HPGDHTTL3MBTL1EPHX2HSD11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2499146-B1 | TRICYCLIC PYRAZOL AMINE DERIVATIVES | MERCK SERONO SA (CH) | 2016-09-21 | — | — | EP | disclosed |
| WO-2011058149-A1 | TRICYCLIC PYRAZOL AMINE DERIVATIVES | MERCK SERONO S.A. (CH) | 2011-05-19 | — | — | WO | disclosed |