Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 1/20 | 0.67 |
| ▸ | HTT | P42858 | 1/20 | 0.60 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.60 |
| ▸ | RHOA | P61586 | 1/20 | 0.58 |
| ▸ | NPC1 | O15118 | 1/20 | 0.54 |
| ▸ | RAB9A | P51151 | 1/20 | 0.54 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.53 |
| ▸ | PROKR1 | Q8TCW9 | 1/20 | 0.53 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.52 |
| ▸ | MGLL | Q99685 | 1/20 | 0.52 |
| ▸ | GRM3 | Q14832 | 1/20 | 0.51 |
| ▸ | MYC | P01106 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22735405 | 0.92 | HTT (0.63) | HPGDHTTL3MBTL1RHOAEPHX2 | |
| SCHEMBL14220733 | 0.92 | HTT (0.63) | HPGDHTTL3MBTL1RHOAEPHX2 | |
| SCHEMBL8053380 | 0.86 | HPGD (0.67) | HPGDHTTL3MBTL1RHOANPC1 | |
| SCHEMBL2667154 | 0.85 | HPGD (0.64) | HPGDHTTL3MBTL1EPHX2HSD11B1 | |
| SCHEMBL12449540 | 0.83 | HPGD (0.51) | HPGDHTTRHOANPC1RAB9A | |
| SCHEMBL18082577 | 0.83 | HPGD (0.62) | HPGDHTTL3MBTL1RHOANPC1 | |
| SCHEMBL12419 | 0.83 | HPGD (0.62) | HPGDHTTL3MBTL1RHOANPC1 | |
| SCHEMBL10194853 | 0.82 | GRM3 (0.62) | HPGDEPHX2PROKR1GRM3ALDH1A1 | |
| SCHEMBL12977 | 0.82 | HPGD (0.69) | HPGDHTTL3MBTL1EPHX2HSD11B1 | |
| SCHEMBL10194846 | 0.82 | GRM3 (0.62) | HPGDEPHX2PROKR1GRM3ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017155910-A1 | THIAZOLIDINONE COMPOUNDS AND USE THEREOF | NATIONAL HEALTH RESEARCH INSTITUTES (TW) | 2017-09-14 | — | — | WO | disclosed |
| EP-2499146-B1 | TRICYCLIC PYRAZOL AMINE DERIVATIVES | MERCK SERONO SA (CH) | 2016-09-21 | — | — | EP | disclosed |
| WO-2011058149-A1 | TRICYCLIC PYRAZOL AMINE DERIVATIVES | MERCK SERONO S.A. (CH) | 2011-05-19 | — | — | WO | disclosed |