Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 2/20 | 0.64 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.60 |
| ▸ | MGLL | Q99685 | 1/20 | 0.60 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.57 |
| ▸ | GABRD | O14764 | 1/20 | 0.56 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.56 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.56 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.56 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.56 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.56 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.56 |
| ▸ | GABRA4 | P48169 | 1/20 | 0.56 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.55 |
| ▸ | HTT | P42858 | 1/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.54 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | UBE2M | P61081 | 1/20 | 0.53 |
| ▸ | DCUN1D1 | Q96GG9 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8299183 | 0.84 | FAAH (0.65) | HPGDMGLLHTTMEN1KMT2A | |
| SCHEMBL12419 | 0.84 | HPGD (0.62) | HPGDHSD11B1MGLLEPHX2HTT | |
| SCHEMBL8054515 | 0.84 | HPGD (0.69) | HPGDHSD11B1MGLLEPHX2GABRD | |
| SCHEMBL12977 | 0.84 | HPGD (0.69) | HPGDHSD11B1MGLLEPHX2GABRD | |
| SCHEMBL7130857 | 0.83 | HPGD (0.83) | HPGDHSD11B1MGLLGABRDGABRA1 | |
| SCHEMBL14238822 | 0.83 | HPGD (0.83) | HPGDHSD11B1MGLLGABRDGABRA1 | |
| SCHEMBL9633319 | 0.83 | HPGD (0.57) | HPGDHSD11B1MGLLEPHX2GABRD | |
| SCHEMBL23417312 | 0.82 | HPGD (0.68) | HPGDHSD11B1MGLLEPHX2GABRD | |
| SCHEMBL9633335 | 0.82 | HPGD (0.68) | HPGDHSD11B1MGLLEPHX2GABRD | |
| SCHEMBL10195735 | 0.82 | KMT2A (0.65) | HPGDHSD11B1MGLLEPHX2GABRD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5096900-A | Antidepressants, anxiolytic agents | SYNTHELABO (FR) | 1992-03-17 | — | — | US | disclosed |
| US-5081128-A | Antidepressants, anxiolytic agents | SYNTHELABO (FR) | 1992-01-14 | — | — | US | disclosed |
| US-4977159-A | HYPOTENSIVE AGENTS | SYNTHELABO (FR) | 1990-12-11 | — | — | US | disclosed |
| US-4945096-A | Treatment of a depressive state with 2-[(4-piperidyl)methyl]-1,2,3,4-tetrahydroisoquinoline derivates | SYNTHELABO (FR) | 1990-07-31 | — | — | US | disclosed |
| US-4931449-A | 2-((4-piperidyl)methyl)benzofuro(2,3-C)pyridine derivatives, and their application in therapy | SYNTHELABO (FR) | 1990-06-05 | — | — | US | disclosed |
| US-4925850-A | SLEEP, CARDIOVASCULAR, AND NERVOUS SYSTEM DISORDERS; DIETETICS, ANXIOLYTIC AGENTS | SYNTHELABO (FR) | 1990-05-15 | — | — | US | disclosed |
| US-4885302-A | 2-((4-Piperidyl)methyl)-1,2,3,4-tetrahydroisoquinoline derivatives, their preparation and their application in therapy | SYNTHELABO, 58, RUE DE LA GLACIERE - 75013 PARIS | 1989-12-05 | — | — | US | disclosed |