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SCHEMBL12420233

SCHEMBL12420233

CN(CCc1ccc(B(O)O)c(F)c1)C(=O)OC(C)(C)C

nearest known ligand 0.37

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ PDK2 Q15119 1/20 0.37
▸ ACHE P22303 2/20 0.34
▸ MEN1 O00255 1/20 0.34
▸ KMT2A Q03164 1/20 0.34
▸ ESRRG P62508 1/20 0.34
▸ HTR2C P28335 2/20 0.33
▸ SLC6A4 P31645 2/20 0.33
▸ CDK8 P49336 1/20 0.33
▸ CLK4 Q9HAZ1 1/20 0.33
▸ MCHR1 Q99705 1/20 0.33
▸ TAAR1 Q96RJ0 1/20 0.33
▸ HTR2A P28223 1/20 0.32
▸ CACNA1G O43497 1/20 0.32
▸ CACNA1B Q00975 1/20 0.32
▸ CACNA1C Q13936 1/20 0.32
▸ RIPK1 Q13546 1/20 0.32
▸ GLS O94925 1/20 0.32
▸ CCNE2 O96020 1/20 0.32
▸ CCNE1 P24864 1/20 0.32
▸ CDK2 P24941 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29677595 0.85 ESRRG (0.39) PDK2ACHEESRRG
SCHEMBL28733797 0.85 ESRRG (0.39) PDK2ACHEESRRG
SCHEMBL1129072 0.84 SSTR4 (0.39) PDK2ACHEKMT2AESRRGHTR2C
SCHEMBL12420011 0.80 LPL (0.44) PDK2ESRRG
SCHEMBL5347625 0.80 CDK8 (0.45) MEN1KMT2ACDK8CLK4
SCHEMBL14326997 0.80 TAAR1 (0.50) PDK2ESRRGMCHR1TAAR1RIPK1
SCHEMBL16659614 0.79 PDK2 (0.36) PDK2ACHEESRRGHTR2CSLC6A4
SCHEMBL28733725 0.77 ESRRG (0.37) PDK2ACHEESRRGGLS
SCHEMBL29677359 0.77 ESRRG (0.37) PDK2ACHEESRRGGLS
SCHEMBL2240309 0.76 PPARA (0.44) PDK2ESRRGHTR2CSLC6A4GBA1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20150368278-A1 INHIBITORS OF FATTY ACID AMIDE HYDROLASE INFINITY PHARMACEUTICALS, INC. (US) 2015-12-24 — — US disclosed
US-20150368278-A1 INHIBITORS OF FATTY ACID AMIDE HYDROLASE INFINITY PHARMACEUTICALS, INC. (US) 2015-12-24 — — US disclosed
US-8957049-B2 Inhibitors of fatty acid amide hydrolase INFINITY PHARMACEUTICALS, INC. (US) 2015-02-17 — — US disclosed
US-8957049-B2 Inhibitors of fatty acid amide hydrolase INFINITY PHARMACEUTICALS, INC. (US) 2015-02-17 — — US disclosed
US-20110172186-A1 INHIBITORS OF FATTY ACID AMIDE HYDROLASE INFINITY PHARMACEUTICALS, INC. 2011-07-14 — — US disclosed
US-20110172186-A1 INHIBITORS OF FATTY ACID AMIDE HYDROLASE INFINITY PHARMACEUTICALS, INC. 2011-07-14 — — US disclosed
WO-2009126691-A1 INHIBITORS OF FATTY ACID AMIDE HYDROLASE INFINITY PHARMACEUTICALS, INC (US) 2009-10-15 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110172186-A1 INHIBITORS OF FATTY ACID AMIDE HYDROLASE FAAH, FAAH2, ASAH1 PDK2 2412/4885ACHE 445/4885MEN1 4220/4885
US-20150368278-A1 INHIBITORS OF FATTY ACID AMIDE HYDROLASE FAAH, FAAH2, ASAH1 PDK2 2412/4885ACHE 445/4885MEN1 4220/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.