Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B1 | P14061 | 2/20 | 0.56 |
| ▸ | HSD17B2 | P37059 | 2/20 | 0.56 |
| ▸ | S1PR1 | P21453 | 2/20 | 0.50 |
| ▸ | FLT3 | P36888 | 1/20 | 0.50 |
| ▸ | GSK3B | P49841 | 1/20 | 0.50 |
| ▸ | ESRRA | P11474 | 1/20 | 0.49 |
| ▸ | STS | P08842 | 2/20 | 0.45 |
| ▸ | KEAP1 | Q14145 | 4/20 | 0.45 |
| ▸ | NFE2L2 | Q16236 | 4/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | SNCA | P37840 | 1/20 | 0.44 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.44 |
| ▸ | RELA | Q04206 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | CA12 | O43570 | 1/20 | 0.44 |
| ▸ | CA1 | P00915 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23557572 | 0.91 | HSD17B1 (0.71) | HSD17B1HSD17B2S1PR1FLT3GSK3B | |
| SCHEMBL12420391 | 0.88 | STS (0.59) | HSD17B1HSD17B2S1PR1FLT3GSK3B | |
| SCHEMBL12420291 | 0.87 | S1PR1 (0.59) | HSD17B1HSD17B2S1PR1FLT3KEAP1 | |
| SCHEMBL12420390 | 0.87 | KEAP1 (0.58) | HSD17B1HSD17B2S1PR1STSKEAP1 | |
| SCHEMBL1429953 | 0.83 | STIM1 (0.62) | HSD17B1HSD17B2S1PR1KEAP1NFE2L2 | |
| SCHEMBL28003857 | 0.82 | KEAP1 (0.72) | HSD17B1HSD17B2S1PR1FLT3GSK3B | |
| SCHEMBL23557575 | 0.82 | STS (0.72) | HSD17B1HSD17B2FLT3GSK3BESRRA | |
| SCHEMBL12508617 | 0.81 | HSD17B1 (0.45) | HSD17B1HSD17B2S1PR1FLT3GSK3B | |
| SCHEMBL1432929 | 0.81 | ESRRA (0.57) | HSD17B1HSD17B2S1PR1ESRRASTS | |
| SCHEMBL18031098 | 0.78 | S1PR1 (0.60) | HSD17B1HSD17B2S1PR1FLT3MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130096165-A1 | COMPOUNDS AND METHODS FOR MODULATING G PROTEIN-COUPLED RECEPTORS | IRM LLC (BM) | 2013-04-18 | — | — | US | disclosed |
| US-8362050-B2 | Compounds and methods for modulating G protein-coupled receptors | IRM LLC (BM) | 2013-01-29 | — | — | US | disclosed |
| US-20110172278-A1 | COMPOUNDS AND METHODS FOR MODULATING G PROTEIN-COUPLED RECEPTORS | IRM LLC (BM) | 2011-07-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130096165-A1 | COMPOUNDS AND METHODS FOR MODULATING G PROTEIN-COUPLED RECEPTORS | GRK2, GRK3, GPR3 | HSD17B1 2409/4885HSD17B2 2073/4885S1PR1 512/4885 |
| US-20110172278-A1 | COMPOUNDS AND METHODS FOR MODULATING G PROTEIN-COUPLED RECEPTORS | GRK2, GRK3, GPR3 | HSD17B1 2409/4885HSD17B2 2073/4885S1PR1 512/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.