Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNA5 | P22460 | 12/20 | 0.56 |
| ▸ | KCNH2 | Q12809 | 7/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1243163 | 0.82 | KCNA5 (0.60) | KCNA5KCNH2CYP2C9CYP2C19 | |
| SCHEMBL1243322 | 0.81 | KCNA5 (0.59) | KCNA5KCNH2LMNAHPGDHTT | |
| SCHEMBL9902165 | 0.80 | KCNA5 (0.58) | KCNA5KCNH2SMN1; SMN2 | |
| SCHEMBL9901968 | 0.80 | KCNA5 (0.58) | KCNA5KCNH2SMN1; SMN2 | |
| SCHEMBL1242273 | 0.80 | KCNA5 (0.56) | KCNA5KCNH2LMNAEPHX2HPGD | |
| SCHEMBL1240478 | 0.80 | KCNA5 (0.55) | KCNA5KCNH2SMN1; SMN2CYP2C9CYP2C19 | |
| SCHEMBL1242962 | 0.78 | KCNA5 (0.52) | KCNA5KCNH2CYP2C9CYP2C19 | |
| SCHEMBL4186497 | 0.78 | KCNA5 (0.55) | KCNA5KCNH2LMNAEPHX2HPGD | |
| SCHEMBL1243109 | 0.77 | KCNA5 (0.51) | KCNA5KCNH2LMNAEPHX2HPGD | |
| SCHEMBL1243112 | 0.77 | KCNA5 (0.51) | KCNA5KCNH2LMNAEPHX2HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7879839-B2 | For treatment and prevention of cardiac arrhythmias; (+-)-2-Morpholin-4-yl-2-phenyl-1,1-dipyridin-3-yl-ethanol; (+-)-2-[(2-methoxyethyl)(methyl)amino]-2-phenyl-1,1-dipyridin-3-ylethanol | MERCK SHARP & DOHME CORP. (US) | 2011-02-01 | — | — | US | disclosed |