Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 3/20 | 0.47 |
| ▸ | NAMPT | P43490 | 4/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | KCNA5 | P22460 | 5/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.45 |
| ▸ | CHRNA7 | P36544 | 3/20 | 0.44 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.44 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.44 |
| ▸ | ITK | Q08881 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1242295 | 1.00 | CYP3A4 (0.47) | CYP3A4NAMPTALDH1A1LMNAGAA | |
| SCHEMBL1242161 | 0.83 | KCNA5 (0.51) | ALDH1A1LMNASMN1; SMN2KCNA5KCNH2 | |
| SCHEMBL1242260 | 0.81 | KCNA5 (0.50) | LMNASMN1; SMN2KCNA5KCNH2 | |
| SCHEMBL1242489 | 0.81 | KCNA5 (0.50) | LMNASMN1; SMN2KCNA5KCNH2 | |
| SCHEMBL1242484 | 0.81 | KCNA5 (0.50) | LMNASMN1; SMN2KCNA5KCNH2 | |
| SCHEMBL9901968 | 0.80 | KCNA5 (0.58) | SMN1; SMN2KCNA5KCNH2 | |
| SCHEMBL9902165 | 0.80 | KCNA5 (0.58) | SMN1; SMN2KCNA5KCNH2 | |
| SCHEMBL4577826 | 0.78 | KCNA5 (0.53) | ALDH1A1KCNA5KCNH2 | |
| SCHEMBL1242273 | 0.77 | KCNA5 (0.56) | LMNAHTTSMN1; SMN2KCNA5KCNH2 | |
| SCHEMBL1240787 | 0.76 | KCNA5 (0.53) | CYP3A4ALDH1A1GAAKCNA5CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7879839-B2 | For treatment and prevention of cardiac arrhythmias; (+-)-2-Morpholin-4-yl-2-phenyl-1,1-dipyridin-3-yl-ethanol; (+-)-2-[(2-methoxyethyl)(methyl)amino]-2-phenyl-1,1-dipyridin-3-ylethanol | MERCK SHARP & DOHME CORP. (US) | 2011-02-01 | — | — | US | disclosed |
| US-20080090794-A1 | Potassium Channel Inhibitors | MERCK SHARP & DOHME LLC | 2008-04-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080090794-A1 | Potassium Channel Inhibitors | KCNJ2, KCNQ2, KCNH2 | CYP3A4 1526/4885NAMPT 1389/4885ALDH1A1 2989/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.