Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FPR1 | P21462 | 7/20 | 0.47 |
| ▸ | FPR2 | P25090 | 4/20 | 0.47 |
| ▸ | AKT1 | P31749 | 13/20 | 0.42 |
| ▸ | AKT2 | P31751 | 3/20 | 0.41 |
| ▸ | SGK1 | O00141 | 2/20 | 0.40 |
| ▸ | RPS6KB1 | P23443 | 2/20 | 0.40 |
| ▸ | PRKCQ | Q04759 | 2/20 | 0.40 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.40 |
| ▸ | RPS6KA1 | Q15418 | 2/20 | 0.40 |
| ▸ | AKT3 | Q9Y243 | 2/20 | 0.40 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5924077 | 0.87 | CHRNB2 (0.40) | FPR1FPR2AKT1AKT2 | |
| SCHEMBL1721284 | 0.85 | FPR1 (0.47) | FPR1FPR2AKT1AKT2SGK1 | |
| SCHEMBL12891129 | 0.82 | FPR1 (0.46) | FPR1FPR2AKT1AKT2SGK1 | |
| SCHEMBL13178100 | 0.82 | FPR1 (0.46) | FPR1FPR2AKT1AKT2SGK1 | |
| SCHEMBL1721363 | 0.82 | KDM1A (0.50) | FPR1FPR2AKT1 | |
| SCHEMBL12891133 | 0.81 | ALDH1A1 (0.44) | FPR1FPR2 | |
| SCHEMBL8262488 | 0.81 | ALDH1A1 (0.44) | FPR1FPR2 | |
| SCHEMBL4394747 | 0.76 | DPP4 (0.37) | FPR1FPR2 | |
| SCHEMBL1528368 | 0.76 | DPP4 (0.37) | FPR1FPR2 | |
| SCHEMBL2420370 | 0.76 | FPR1 (0.52) | FPR1FPR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7884104-B2 | Such as (3R,4R)-1-Pyrimidin-4-yl-4-(2,4,5-trifluorophenyl)piperidin-3-amine bis-trifluoroacetic acid salt | MERCK SHARP & DOHME CORP. (US) | 2011-02-08 | — | — | US | disclosed |
| EP-1796669-B1 | AMINOPIPERIDINES AS DIPEPTIDYL PEPTIDASE-IV INHIBITORS FOR THE TREATMENT OR PREVENTION OF DIABETES | MERCK SHARP & DOHME (US) | 2010-09-22 | — | — | EP | disclosed |