SCHEMBL12424951

SCHEMBL12424951

O=C1NC(c2cc(C(F)(F)F)ccc2Cl)=C2C(=O)NC(c3cc(C(F)(F)F)ccc3Cl)=C12

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
STK10 O94804 1/20 0.47
SLK Q9H2G2 1/20 0.47
TDP2 O95551 2/20 0.42
PARP1 P09874 1/20 0.42
PARP10 Q53GL7 1/20 0.42
JUN P05412 4/20 0.39
NFKB1 P19838 4/20 0.39
NFKB2 Q00653 4/20 0.39
RELA Q04206 4/20 0.39
MEN1 O00255 2/20 0.39
KMT2A Q03164 2/20 0.39
ALDH1A1 P00352 1/20 0.39
TSHR P16473 1/20 0.39
ATM Q13315 1/20 0.39
L3MBTL1 Q9Y468 1/20 0.39
BIRC5 O15392 2/20 0.39
IL2 P60568 1/20 0.38
LMNA P02545 1/20 0.37
HSD17B10 Q99714 1/20 0.37
RAD51 Q06609 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12425015 0.79 TDP2 (0.46) STK10SLKTDP2PARP1PARP10
SCHEMBL12424906 0.78 PPOX (0.52) STK10SLKPARP1PARP10ALDH1A1
SCHEMBL19785385 0.76 PDE2A (0.47) MEN1KMT2AALDH1A1TSHRATM
SCHEMBL12424949 0.73 MASP2 (0.45) TDP2MEN1KMT2AALDH1A1TSHR
SCHEMBL12424740 0.72 TDP2 (0.45) TDP2
SCHEMBL12509636 0.72 TDP2 (0.40) TDP2PARP1PARP10MEN1KMT2A
SCHEMBL12425024 0.71 AKR1C3 (0.40) STK10SLKTDP2PARP10
SCHEMBL12424903 0.70 NOTUM (0.48) STK10SLKPARP10
SCHEMBL5194204 0.70 TDP2 (0.59) TDP2PARP1PARP10JUNNFKB1
SCHEMBL31586640 0.70 TDP2 (0.59) TDP2PARP1PARP10JUNNFKB1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7977670-B2 Organic transistor TOYO INK MFG. CO., LTD. (JP) 2011-07-12 US disclosed
US-20100032657-A1 ORGANIC TRANSISTOR TOYO INK MFG CO., LTD (JP) 2010-02-11 US disclosed