Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 1/20 | 0.46 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.46 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.46 |
| ▸ | TEAD1 | P28347 | 2/20 | 0.43 |
| ▸ | TRPC6 | Q9Y210 | 1/20 | 0.42 |
| ▸ | HRH3 | Q9Y5N1 | 7/20 | 0.38 |
| ▸ | JAK2 | O60674 | 1/20 | 0.38 |
| ▸ | JAK1 | P23458 | 1/20 | 0.38 |
| ▸ | JAK3 | P52333 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.35 |
| ▸ | IL6 | P05231 | 1/20 | 0.35 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17409812 | 0.91 | TRPC6 (0.43) | KCNH2SCN5ASCN9ATEAD1TRPC6 | |
| SCHEMBL26031622 | 0.91 | TRPC6 (0.43) | KCNH2SCN5ASCN9ATEAD1TRPC6 | |
| SCHEMBL17828175 | 0.87 | ALDH1A1 (0.48) | KCNH2SCN5ASCN9AHRH3TSHR | |
| SCHEMBL14325 | 0.86 | KCNH2 (0.45) | KCNH2SCN5ASCN9ATEAD1TRPC6 | |
| SCHEMBL16132004 | 0.83 | HRH3 (0.49) | KCNH2SCN5ASCN9AHRH3PDE10A | |
| SCHEMBL12894384 | 0.83 | HRH3 (0.53) | KCNH2SCN5ASCN9AHRH3 | |
| SCHEMBL12310670 | 0.82 | HRH3 (0.53) | HRH3 | |
| SCHEMBL12064 | 0.81 | HRH3 (0.55) | KCNH2SCN5ASCN9AHRH3 | |
| SCHEMBL31469718 | 0.81 | TEAD1 (0.48) | TEAD1HRH3JAK2JAK1JAK3 | |
| SCHEMBL12449613 | 0.80 | TEAD1 (0.51) | KCNH2TEAD1HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2499146-B1 | TRICYCLIC PYRAZOL AMINE DERIVATIVES | MERCK SERONO SA (CH) | 2016-09-21 | — | — | EP | disclosed |
| WO-2011058149-A1 | TRICYCLIC PYRAZOL AMINE DERIVATIVES | MERCK SERONO S.A. (CH) | 2011-05-19 | — | — | WO | disclosed |