Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 15/20 | 0.70 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.58 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.58 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.58 |
| ▸ | HTR2B | P41595 | 2/20 | 0.53 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7138409 | 0.91 | HTR6 (0.59) | HTR6L3MBTL1TDP1NPSR1HTR2B | |
| SCHEMBL12427018 | 0.91 | HTR6 (0.69) | HTR6L3MBTL1TDP1NPSR1KDM4E | |
| SCHEMBL12441273 | 0.91 | HTR6 (0.63) | HTR6HTR2BKCNH2 | |
| SCHEMBL7136576 | 0.91 | HTR6 (0.60) | HTR6L3MBTL1TDP1NPSR1HTR2B | |
| SCHEMBL12428285 | 0.91 | HTR6 (0.60) | HTR6HTR2BKCNH2 | |
| SCHEMBL12428309 | 0.89 | HTR6 (0.68) | HTR6HTR2BKCNH2 | |
| SCHEMBL12428284 | 0.89 | HTR6 (0.61) | HTR6L3MBTL1TDP1NPSR1KDM4E | |
| SCHEMBL12427110 | 0.86 | HTR6 (0.53) | HTR6HTR2BKCNH2 | |
| SCHEMBL12428356 | 0.85 | HTR6 (0.81) | HTR6L3MBTL1TDP1NPSR1 | |
| SCHEMBL12427020 | 0.83 | HTR6 (0.71) | HTR6HTR2BKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3020719-A1 | SUBSTITUTED 3-ARYLSULFONYL-PYRAZOLO[1,5-A]PYRIMIDINES, SEROTONIN 5-HT6 RECEPTOR ANTAGONISTS AND METHODS FOR THE PRODUCTION AND USE THEREOFAND METHODS FOR THE PRODUCTION AND USE THEREOF | Alla Chem, LLC. (US) | 2016-05-18 | — | — | EP | disclosed |
| EP-2351756-A1 | SUBSTITUTED 3-ARYLSULFONYL-PYRAZOLO[1,5-A]PYRIMIDINES, SEROTONIN 5-HT6 RECEPTOR ANTAGONISTS AND METHODS FOR THE PRODUCTION AND USE THEREOF | Ivashchenko, Andrey Alexandrovich (RU) | 2011-08-03 | — | — | EP | disclosed |
| US-20110178078-A1 | SUBSTITUTED 3-ARYLSULFONYL-PYRAZOLO[1,5-A]PYRIMIDINES, SEROTONIN 5-HT6 RECEPTOR ANTAGONISTS AND METHODS FOR THE PRODUCTION AND USE THEREOF | IVASHCHENKO ANDREY ALEXANDROVICH | 2011-07-21 | — | — | US | disclosed |
| WO-2010041983-A1 | SUBSTITUTED 3-ARYLSULFONYL-PYRAZOLO[1,5-A]PYRIMIDINES, SEROTONIN 5-HT6 RECEPTOR ANTAGONISTS AND METHODS FOR THE PRODUCTION AND USE THEREOF | АЛЛА ХЕМ, ЛЛС (US) | 2010-04-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110178078-A1 | SUBSTITUTED 3-ARYLSULFONYL-PYRAZOLO[1,5-A]PYRIMIDINES, SEROTONIN 5-HT6 RECEPTOR ANTAGONISTS AND METHODS FOR THE PRODUCTION AND USE THEREOF | HTR6, HTR1A, HTR3A | HTR6 1/4885L3MBTL1 2174/4885TDP1 1081/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.