Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | FAAH | O00519 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.40 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.40 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.40 |
| ▸ | CHRNB3 | Q05901 | 1/20 | 0.40 |
| ▸ | CHRNA6 | Q15825 | 1/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | XBP1 | P17861 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | EPHX2 | P34913 | 5/20 | 0.38 |
| ▸ | NAMPT | P43490 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1753627 | 0.82 | EPHX2 (0.53) | MEN1ALDH1A1KMT2AFAAHL3MBTL1 | |
| SCHEMBL621434 | 0.82 | MEN1 (0.44) | MEN1ALDH1A1KMT2AFAAHL3MBTL1 | |
| SCHEMBL15730412 | 0.81 | MEN1 (0.47) | MEN1ALDH1A1KMT2AFAAHL3MBTL1 | |
| SCHEMBL6028911 | 0.81 | MEN1 (0.43) | MEN1ALDH1A1KMT2AFAAHL3MBTL1 | |
| SCHEMBL12413676 | 0.81 | NCF1 (0.47) | MEN1ALDH1A1KMT2AFAAHL3MBTL1 | |
| SCHEMBL3317367 | 0.81 | MEN1 (0.43) | MEN1ALDH1A1KMT2AFAAHL3MBTL1 | |
| SCHEMBL23188105 | 0.79 | ITGB3 (0.51) | MEN1ALDH1A1KMT2AFAAHL3MBTL1 | |
| SCHEMBL25924562 | 0.79 | FAAH (0.45) | MEN1ALDH1A1KMT2AFAAHL3MBTL1 | |
| SCHEMBL18513691 | 0.79 | FAAH (0.48) | MEN1ALDH1A1KMT2AFAAHL3MBTL1 | |
| SCHEMBL25737219 | 0.79 | FAAH (0.48) | MEN1ALDH1A1KMT2AFAAHL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011101429-A1 | PYRIDO[3,2-D]PYRIMIDINE PI3K DELTA INHIBITOR COMPOUNDS AND METHODS OF USE | F. HOFFMANN-LA ROCHE AG (CH) | 2011-08-25 | — | — | WO | disclosed |